[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600708":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":41,"collaborators":26,"id":45,"slug":26,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":26,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":26,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":73,"whyStopped":26,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":26},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Multiple instrumentation","ACTIVE_COMPARATOR","root canal instrumentation will be done on two visits as a control",[13],"Procedure: multiple visit instrumentation",{"label":15,"type":16,"description":17,"interventionNames":18},"single instrumentation","EXPERIMENTAL","Root canal instrumentation will be done on one visits",[19],"Procedure: single visit instrumentation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","single visit instrumentation","root canal instrumentation will be done on single visit treatment",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"multiple visit instrumentation","root canal treatment will be done on two visits",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Marwa Hisham Mohamed, MSc","CONTACT","00201007096807","Marwa_hisham@dentistry.cu.edu.eg",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Maruim Hisham Eissa, MSc","00201001714432","Mariam.abdelfattah@dentistry.cu.edu.eg",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Marwa Hisham Mohamed Salah Eldin","Principal Investigator","100600708",false,"NCT07101003","A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits","A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age between 18-40 years.\n* Males\u002FFemales.\n* Straight single canaled permanent teeth:\n\n  * Non-Vital pulps.\n  * Negative response to cold pulp tester (ethyl chloride spray\\*).\n  * Absence of spontaneous pain.\n  * Chronic apical periodontitis with negative response to percussion\n  * Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\\*2 mm radiographically. The Periapical Index (PAI) score by Ørstavik is 2 or 3 (Ørstavik et al., 1986 43)\n* Systemically healthy patients (ASA I or II)\n* No anti-inflammatory or antibiotic medications taken in the past month\n* Patients' acceptance to participate in the trial.\n* Patients who can understand pain scale and can sign the informed consent (Appendix I).\n* Patients' acceptance to participate in the trial.\n\nExclusion Criteria:\n\n* Medically compromised patients having significant systemic disorders. (ASA III or IV).\n* Teeth with swelling or fistulous tract.\n* Teeth with acute or chronic periapical abscess.\n* Mobility Grade II or III.\n* Previous root canal therapy.\n* Non-restorable teeth.\n* Immature teeth.\n* Pregnant females.","ALL","18 Years","40 Years",{"count":55,"type":56},28,"ESTIMATED","INTERVENTIONAL",[59],"NA","This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.",[62,63,64],"Apical Periodontitis","Necrotic Pulps","Single Rooted Teeth",[66,67,68,69,70,71,72],"necrotic pulps","root canal system","Enterococcus faecalis (E. faecalis)","Microbioogy","pain","bacterial reduction","Matrix metalloproteinases (MMPs)","NOT_YET_RECRUITING","2025-07-28",{"date":76,"type":77},"2025-08-03","ACTUAL",{"date":79,"type":56},"2025-08-01",{"date":81,"type":56},"2025-08-04",{"name":43,"class":6}]