[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553875":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":52,"collaborators":25,"id":55,"slug":25,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":25,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":25,"overallStatus":74,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Mahidol University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"cryotherapy with tranexamic acid","ACTIVE_COMPARATOR","precision cryotherapy via boosting mode combined with tranexamic acid",[13],"Device: TargetCool",{"label":15,"type":16,"description":17,"interventionNames":18},"cryotherapy with normal saline","PLACEBO_COMPARATOR","precision cryotherapy via boosting mode combined with normal saline",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","TargetCool","The patients were treated with TargetCool via boosting mode combined with tranexamic acid and normal saline on each side of cheek for 4 times every 1 week",[15,9],null,[27],{"name":28,"affiliation":5,"role":29},"Woraphong Manuskiatti, MD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},"CONTACT","6624194333","doctorlaser@gmail.com",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Supisara Wongdama, MD","66869898613","popsupdm@gmail.com",[40],{"facility":41,"status":25,"city":42,"state":25,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":25},"Department of Dermatology, Siriraj Hospital, Mahidol University","Bangkok","10700","Thailand","TH",{"type":47,"coordinates":48},"Point",[49,50],100.50144,13.75398,{"lat":50,"lon":49},{"type":29,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Woraphong Manuskiatti, M.D.","Prof. Dr.","100553875",false,"NCT06491771","A Cryotherapy With Tranexamic Acid Versus Normal Saline in the Treatment of Melasma","A Randomized Split-face Study of a Precision Cryotherapy Via Boosting Mode Combined With Tranexamic Acid Versus Normal Saline in the Treatment of Melasma","Inclusion Criteria:\n\n* The patients diagnosed with epidermal-type melasma sized equal to or more than 2 cm on both sides of cheeks\n* Fitzpatrick skin type II-IV\n\nExclusion Criteria:\n\n* Pregnant or lactation\n* Subjects who have been treated with any kind of energy-based device 6 months prior to the inclusion\n* Subjects who have been treated with topical or oral treatment for melasma 6 months prior to the inclusion\n* Subjects who allergy to cryotherapy such as cryoglobulinemia, cold urticaria, and abnormal cold tolerance\n* Subjects with abnormal sensation such as diabetes mellitus\n* Active skin infections\n* History of hypertrophic scars or keloids History of hypertrophic scars or keloids",true,"ALL","25 Years","60 Years",{"count":66,"type":67},18,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study aimed to evaluate the effectiveness of a precision cryotherapy via boosting mode combined with tranexamic acid versus normal saline in the treatment of melasma. Eighteen patients aged 25 to 60 years diagnosed with epidermal-typed melasma sized equal to or more than 2 cm on both cheeks were included. The patients were treated with a precision cryotherapy via boosting mode combined with tranexamic acid and normal saline on each side of cheek for 4 times every 1 week. Then, they were follow up at 1 and 3 months after the last treatment. Subjective assessment of physician and patient improvement were evaluated. Moreover, Melasma Area and Severity Index (MASI), melanin and erythema index using Mexameter were also recorded.",[73],"Cryotherapy Effect","NOT_YET_RECRUITING","2024-07-03",{"date":77,"type":78},"2024-07-09","ACTUAL",{"date":80,"type":67},"2024-07-01",{"date":82,"type":67},"2025-07-01",{"name":5,"class":6},1]