[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100531275":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":37,"centralContacts":41,"locations":46,"responsibleParty":63,"collaborators":66,"id":69,"slug":26,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Kessler Foundation","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive Rehabilitation + Aerobic Exercise with Virtual Reality (VR)","EXPERIMENTAL","In the cognitive rehabilitation and aerobic exercise with VR condition, participants will complete a supervised, aerobic exercise training program (AET) integrated with virtual reality (Ideally Designed Exercise to Accelerate Learning\u002Fmemory; IDEAL) three days per week over a 12 week period. For seven weeks, participants will only complete IDEAL. For weeks 8-12, participants will complete the Kessler Foundation modified story Memory Technique (KF-mSMT®), a memory retraining program on 2 of the 3 days per week.",[13,14],"Behavioral: The Kessler Foundation modified Story Memory Technique® (KF-mSMT®)","Behavioral: Aerobic Exercise Training (AET) plus Virtual Reality (IDEAL)",{"label":16,"type":10,"description":17,"interventionNames":18},"Cognitive Rehabilitation + Stretching and Toning","In the cognitive rehabilitation and stretching and toning (S\u002FT) exercise condition, participants will complete 12 weeks of supervised S\u002FT activities 3 days per week over the 12 week period. For seven weeks, participants will only complete S\u002FT. During weeks 8-12, participants will complete the Kessler Foundation modified story Memory Technique (KF-mSMT®), a memory retraining program on 2 of the 3 days per week.",[13,19],"Behavioral: Stretching and Toning (S\u002FT)",[21,27,33],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","The Kessler Foundation modified Story Memory Technique® (KF-mSMT®)","KF-mSMT is a memory retraining technique that consists of two-related skills: (1) imagery and (2) context\u002Forganization. The proposed KF-mSMT intervention includes 10 total sessions with 2 sessions per week for 5 weeks. Each session will last 45-60 minutes.",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Aerobic Exercise Training (AET) plus Virtual Reality (IDEAL)","The AET condition includes 12 weeks of supervised, progressive, moderate intensity cycle ergometry. The AET will include semi-immersive, interactive VR such the cycling speed on the bike will translate directly to perceived speed through the virtual environment.",[9],[32],"IDEAL",{"type":22,"name":34,"description":35,"armGroupLabels":36,"otherNames":26},"Stretching and Toning (S\u002FT)","The S\u002FT condition will include 12 weeks of supervised S\u002FT activities that target the head\u002Fneck. shoulder, elbow\u002Fforearm, hand\u002Fwrist, trunk\u002Fhip, ankle\u002Ffoot.",[16],[38],{"name":39,"affiliation":5,"role":40},"Carly Wender, PhD","PRINCIPAL_INVESTIGATOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":26,"email":45},"CONTACT","(973) 324-8388","cwender@kesslerfoundation.org",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","East Hanover","New Jersey","07936","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-74.36487,40.8201,{"lat":58,"lon":57},[61],{"name":39,"role":43,"phone":62,"phoneExt":26,"email":45},"9732436984",{"type":40,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Carly Wender","Research Scientist",[67],{"name":68,"class":6},"National Multiple Sclerosis Society","100531275",false,"NCT06197685","A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis","COMBINE","Inclusion Criteria:\n\n* Be within the ages of 18 and 70 years of age\n* Speak English as their primary language\n* Confirmed MS diagnosis by a neurologist\n* Be relapse and steroid-free for at least 30 days\n* Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS)\n* Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ)\n* Right handedness\n\nExclusion Criteria:\n\n* History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)\n* Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)\n* Currently use medications that may impact cognition (ex: steroids, benzodiazepines)\n* Currently pregnant\n* Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe)\n* Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)","ALL","18 Years","70 Years",{"count":79,"type":80},78,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.",[86],"Multiple Sclerosis",[86,88,89,90,91],"Aerobic exercise","Virtual Reality","Leg cycling","Mobility disability","2025-08-25",{"date":94,"type":95},"2025-09-02","ACTUAL",{"date":97,"type":95},"2024-02-12",{"date":99,"type":80},"2026-06-30",{"name":5,"class":6},1]