The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP)
Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (>100 colorectal adenomas in combination with a positive family history of FAP)
Age 18 years or older
Endoscopic removal of all polyps with an indication for removal not possible/feasible
Gastric or duodenal cancer at baseline endoscopy
Need for surgery
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead sponsor
Leiden University Medical Center
Collaborator
The Netherlands Cancer Institute
Collaborator
St Mark's Hospital Foundation
Collaborator
Hospital Clinic of Barcelona
Collaborator
Maria Sklodowska-Curie National Research Institute of Oncology
Collaborator
Hospital General Universitario de Alicante
Collaborator
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Collaborator
Radboud University Medical Center
Collaborator
University Hospital, Bonn
Collaborator
Hvidovre University Hospital
Collaborator
M.D. Anderson Cancer Center
Collaborator