About this trial
The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic diseases such as diabetes and cardiovascular disease. In the investigators current Merit supported cohort, the investigators found that 36% of Veterans with treated HIV and obesity have "myosteatotic type obesity". Based on the investigators findings, the investigators have designed a multipronged integrated intervention that combines: 1) dietary replacement of saturated with unsaturated fats; 2) administration of L-carnitine and omega-3 fatty acid supplementation; and 3) targeted resistance exercise training.
Eligibility criteria
Qualifiers
Veteran
HIV+
antiretroviral therapy = integrase strand transfer inhibitor for at least 3 months
HIV-1 RNA <50 copies/ml
Disqualifiers
unstable body weight (gain or loss > 5% over past 3 months)
diagnosed mitochondrial disorder
diagnosed type 1 or type 2 diabetes
use of metformin or other anti-diabetic agents for pre-diabetes
Trial design
Treatments tested in this trial
- w-3 fatty acid
- L-carnitine
- Control Diet