[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621006":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":53,"centralContacts":46,"locations":57,"responsibleParty":77,"collaborators":79,"id":82,"slug":46,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":46,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":89,"maxAge":46,"enrollmentInfo":90,"targetDuration":46,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":46,"overallStatus":59,"whyStopped":46,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Michigan Rogel Cancer Center","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm I (LASO-3 sessions)","EXPERIMENTAL","Patients attend virtual LASO-3 nutrition counseling sessions over 30 minutes QW for 4 weeks followed by LASO-3 nutrition counseling sessions over 15 minutes Q2W for 8 weeks. Patients also undergo blood sample collection throughout the trial.",[13,14,15,16],"Procedure: Biospecimen Collection","Other: Electronic Health Record Review","Other: Interview","Other: Survey Administration",{"label":18,"type":19,"description":20,"interventionNames":21},"Arm II (general health education sessions)","ACTIVE_COMPARATOR","Patients attend eight virtual general health education sessions over 15-30 minutes each over 12 weeks. Patients also undergo blood sample collection throughout the trial. Patients may also receive the intervention materials and up to 4 dietary counseling sessions post-study.",[13,22,14,16],"Other: Educational Intervention",[24,33,42,47,50],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Biospecimen Collection","Undergo blood sample collection",[9,18],[30,31,32],"Biological Sample Collection","Biospecimen Collected","Specimen Collection",{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Educational Intervention","Attend virtual general health education sessions",[18],[38,39,40,41],"Education for Intervention","Intervention by Education","Intervention through Education","Intervention, Educational",{"type":6,"name":43,"description":44,"armGroupLabels":45,"otherNames":46},"Electronic Health Record Review","Ancillary studies",[9,18],null,{"type":6,"name":48,"description":44,"armGroupLabels":49,"otherNames":46},"Interview",[9],{"type":6,"name":51,"description":44,"armGroupLabels":52,"otherNames":46},"Survey Administration",[9,18],[54],{"name":55,"affiliation":5,"role":56},"Robert Knoerl","PRINCIPAL_INVESTIGATOR",[58],{"facility":5,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-83.74088,42.27756,{"lat":69,"lon":68},[72,76],{"name":55,"role":73,"phone":74,"phoneExt":46,"email":75},"CONTACT","734-764-8617","rjknoerl@med.umich.edu",{"name":55,"role":56,"phone":46,"phoneExt":46,"email":46},{"type":78,"investigatorFullName":46,"investigatorTitle":46,"investigatorAffiliation":46,"oldNameTitle":46,"oldOrganization":46},"SPONSOR",[80],{"name":81,"class":6},"Hope Foundation","100621006",false,"NCT07365007","A Virtually Delivered Diet Intervention (LASO-3) for the Improvement of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Post-treatment","Feasibility of a Virtually Delivered LASO-3 Diet Intervention for Chemotherapy-Induced Peripheral Neuropathy in Post-Treatment Cancer Survivors","Inclusion Criteria:\n\n* 18 years or older\n* At least three months since last receiving neurotoxic chemotherapy\n* Self-report moderate (≥ 2\u002F4) numbness and tingling on the Patient Reported Outcomes-Common Terminology Criteria for Adverse Events (PRO-CTCAE™) Numbness and Tingling Severity Item in the last week\n* Speak\u002Fread English\n* Have access to the internet\n\nExclusion Criteria:\n\n* Pre-existing peripheral neuropathy from any cause\n* Plan to begin a new prescription of duloxetine (i.e., first-line treatment for CIPN pain) during the study period\n* Are enrolled in symptom management trials that may alter CIPN severity\n* High grade inflammatory disease such as lupus, Crohn's disease, or rheumatoid arthritis\n* Routine nonsteroidal anti-inflammatory drug (NSAID) or steroid supplementation\n* Consuming an average three or more servings of fish per week and\u002For consuming fish oil capsules containing eicosapentaenoic acid (EPA)+ docosahexaenoic acid (DHA) daily or consuming flax oil capsules daily\n* Consuming an average of less than 5 servings of sweets, candy bars, chocolate, doughnuts, cookies, cakes, pie, brownies, ice cream, pastries, or sugar sweetened beverages (e.g., soda or coffee\u002Ftea) per week","ALL","18 Years",{"count":91,"type":92},50,"ESTIMATED","INTERVENTIONAL",[95],"NA","This clinical trial studies whether a virtually delivered diet intervention focused on lower added sugar, higher fiber, and higher omega 3 fatty acid (LASO-3) can be used to improve chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors after treatment. Cancer survivors often experience CIPN during and after cancer treatment with neurotoxic chemotherapy. CIPN is characterized by nerve damage from chemotherapy that leads to numbness, tingling, or pain in the hands or feet. However, there are few treatments to manage CIPN. Inflammation contributes to the development of CIPN and dietary patterns that have been demonstrated to improve diet quality and reduce inflammation in cancer survivors may be promising for use as a CIPN management strategy. The LASO-3 diet intervention consists of virtually delivered nutrition education sessions provided by a Registered Dietitian. The sessions focus on three dietary goals, informed by the United States Dietary Guidelines for Americans: 1) lowering added sugar intake to \\\u003C 10% of daily calories, 2) increasing daily fiber intake to ≥ 20 grams, and 3) increasing intake of moderate-high omega-3 seafood to three or more servings weekly or 3300-3400 mg\u002Fday of alpha-linolenic acid (e.g., plant-based sources include canola or flaxseed oil, walnuts, or flaxseed or chia seeds). The Registered Dietitian tailors the sessions to the patient based on information and feedback obtained throughout the sessions. The LASO-3 diet intervention may be an effective way to improve CIPN in cancer survivors after treatment.",[98,99,100],"Chemotherapy-Induced Peripheral Neuropathy","Hematopoietic and Lymphatic System Neoplasm","Malignant Solid Neoplasm","2026-06-22",{"date":103,"type":104},"2026-06-25","ACTUAL",{"date":106,"type":104},"2026-02-23",{"date":108,"type":92},"2028-03-01",{"name":5,"class":6},1]