[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100526755":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":130,"collaborators":132,"id":142,"slug":26,"hasResults":143,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":143,"sex":149,"minAge":150,"maxAge":26,"enrollmentInfo":151,"targetDuration":26,"studyType":154,"phases":155,"briefSummary":157,"conditions":158,"keywords":161,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":175},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AI-guided ablation","EXPERIMENTAL","Use of AI guidance to conduct the ablation",[13],"Procedure: Ablation-index guided ventricular tachycardia ablation",{"label":15,"type":16,"description":17,"interventionNames":18},"non-AI guided ablation","ACTIVE_COMPARATOR","Ablation without AI guidance, AI values masked to the operator.",[19],"Procedure: Ventricular tachycardia ablation with no AI-guidance",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Ablation-index guided ventricular tachycardia ablation","As described in arms descriptions",[9],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"Ventricular tachycardia ablation with no AI-guidance",[15],[31],{"name":32,"affiliation":5,"role":33},"Alexander Mazur, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":26,"email":38},"CONTACT","312-942-5020","alexander_mazur@rush.edu",[40,57,78,94,110],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Chicago","Illinois","60614","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-87.65005,41.85003,{"lat":51,"lon":50},[54],{"name":55,"role":36,"phone":37,"phoneExt":26,"email":56},"Henry D Huang, MD","henry_d_huang@rush.edu",{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":45,"countryCode":46,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Mass General Brigham and Women's Hospital","NOT_YET_RECRUITING","Boston","Massachusetts","02115",{"type":48,"coordinates":64},[65,66],-71.05977,42.35843,{"lat":66,"lon":65},[69,73,76],{"name":70,"role":36,"phone":71,"phoneExt":26,"email":72},"Jorge E. Romero, MD","617-732-5241","jeromero@bwh.harvard.edu",{"name":74,"role":36,"phone":71,"phoneExt":26,"email":75},"Obadah Aloum","OALOUM@BWH.HARVARD.EDU",{"name":77,"role":33,"phone":26,"phoneExt":26,"email":26},"Jorge Romero, MD",{"facility":79,"status":59,"city":80,"state":81,"zip":82,"country":45,"countryCode":46,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Medical University of Michigan","Ann Arbor","Michigan","48109",{"type":48,"coordinates":84},[85,86],-83.74088,42.27756,{"lat":86,"lon":85},[89,93],{"name":90,"role":36,"phone":91,"phoneExt":26,"email":92},"Jackson Liang, DO","888-287-1082","liangjac@med.umich.edu",{"name":90,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":95,"status":59,"city":96,"state":97,"zip":98,"country":45,"countryCode":46,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Mayo Clinic","Rochester","Minnesota","55905",{"type":48,"coordinates":100},[101,102],-92.4699,44.02163,{"lat":102,"lon":101},[105,109],{"name":106,"role":36,"phone":107,"phoneExt":26,"email":108},"Konstantinos Siontis, MD","507-422-0549","Siontis.Konstantinos@mayo.edu",{"name":106,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":111,"status":59,"city":112,"state":113,"zip":114,"country":45,"countryCode":46,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"Medical University of South Carolina","Charleston","South Carolina","29425",{"type":48,"coordinates":116},[117,118],-79.93275,32.77632,{"lat":118,"lon":117},[121,125,129],{"name":122,"role":36,"phone":123,"phoneExt":26,"email":124},"Bishnu Dhakal, MD","843-876-2700","dhakalb@musc.edu",{"name":126,"role":36,"phone":127,"phoneExt":26,"email":128},"Chandler Schwede","843-792-5998","schwede@musc.edu",{"name":122,"role":33,"phone":26,"phoneExt":26,"email":26},{"type":131,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[133,135,136,139,140],{"name":134,"class":6},"University of Michigan",{"name":111,"class":6},{"name":137,"class":138},"Biosense Webster, Inc.","INDUSTRY",{"name":95,"class":6},{"name":141,"class":6},"Brigham and Women's Hospital","100526755",false,"NCT06138873","Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy","Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy (AIM-VT) - a Prospective Single-Blinded, Multicenter Randomized Controlled Trial","AIM-VT","Inclusion Criteria:\n\n* Patient ≥ 18 y.o.\n* Structural Heart Disease: Ischemic Cardiomyopathy\n* Sustained Scar-related Monomorphic Ventricular Tachycardia documented by ECG or CIED interrogation\n\nExclusion Criteria:\n\n* If clinical ventricular arrhythmia is predominantly PVCs, supraventricular tachycardia, or ventricular fibrillation\n* Myocardial infarction or cardiac surgery within 6 months\n* Severe mitral regurgitation\n* Stroke or TIA within 6 months\n* Prior VT substrate ablation in the previous 6 months\n* NYHA functional class IV\n* Non-ischemic VT substrate","ALL","18 Years",{"count":152,"type":153},100,"ESTIMATED","INTERVENTIONAL",[156],"NA","Over the last decade, radiofrequency catheter ablation (RFCA) has become an established treatment for ventricular arrhythmias (VA). Due to the challenging nature of visualizing lesion formation in real time and ensuring an effective transmural lesion, different surrogate measures of lesion quality have been used. The Ablation Index (AI) is a variable incorporating power delivery in its formula and combining it with CF and time in a weighted equation which aims at allowing for a more precise estimation of lesion depth and quality when ablating VAs. AI guidance has previously been shown to improve outcomes in atrial and ventricular ablation in patients with premature ventricular complexes (PVC). However research on outcomes following AI-guidance for VT ablation specifically in patients with structural disease and prior myocardial infarction remains sparse. The investigators aim at conducting the first randomized controlled trial testing for the superiority of an AI-guided approach regarding procedural duration.",[159,160],"Ventricular Tachycardia","Ischemic Cardiomyopathy",[162,163,164,165],"ventricular","tachycardia","ablation index","ischemic cardiomyopathy","2025-09-17",{"date":168,"type":169},"2025-09-22","ACTUAL",{"date":171,"type":169},"2024-10-23",{"date":173,"type":153},"2027-11-23",{"name":5,"class":6},5]