The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where participants receive a single TBS treatment daily) in late life depression. In addition, the study also aims to determine if specific patterns of stimulation are more or less effective. To do this, all participants will receive active treatments, but some of the participants in this study will receive accelerated TBS and some will receive once daily TBS.
are voluntary and competent to consent to treatment
are an outpatient
are ≥ 60 years old
have a Mini International Neuropsychiatric Interview (MINI 7.0) confirmed diagnosis of MDD, with a current MDE
have a Mini International Neuropsychiatric Interview (MINI 7.0) confirmed diagnosis of substance dependence or abuse within the last 3 months
have a concomitant major unstable medical illness as determined by one of the study physicians
have active suicidal intent
have presumed or probable dementia or clinical evidence of dementia as assessed by Short Blessed Test score ≥ 10
Centre for Addiction and Mental Health
Lead sponsor
Sunnybrook Health Sciences Centre
Collaborator