The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.
All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.
Aged 18 to 65
BMI 35 kg/m2
Diagnosed T2D - according to Diabetes Canada diagnostics criteria.
Diagnosed non-T2D - according to Diabetes Canada diagnostics criteria.
Treatment with an oral contraceptive;
Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker, drugs that affect metabolism and cannot be stopped temporarily or which have long-lasting effects;
Presence of overt cardiovascular disease, liver or renal failure or other uncontrolled medical conditions;
Any other contraindication to surgery or to temporarily suspending current medications for diabetes, lipids or hypertension;
Université de Sherbrooke
Lead sponsor
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Collaborator
Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Collaborator