About this trial
The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring.
Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will compare changes in NAFLD over time between young women with and without PCOS.
This study is funded by the National Institutes of Health
Eligibility criteria
Qualifiers
Metabolic associated steatohepatitis (MASH) (formerly NASH)
PCOS
Non-PCOS
Disqualifiers
High levels of alcohol use (more than 7 drinks a week)
Current pregnancy
Other causes of hepatic steatosis
Weight loss of more than 10% body weight in the last 6 months
Trial design
Treatments tested in this trial
- Not listed
Trial groups
Sponsors and collaborators
University of California, San Francisco
Lead sponsor
Duke University
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator