[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100362068":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":41,"centralContacts":45,"locations":51,"responsibleParty":70,"collaborators":11,"id":72,"slug":11,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":11,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":54,"whyStopped":11,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,12,17,21,25],{"label":9,"type":10,"description":11,"interventionNames":11},"Standard protein (control)","NO_INTERVENTION",null,{"label":13,"type":14,"description":11,"interventionNames":15},"High animal protein isolate","EXPERIMENTAL",[16],"Other: High animal protein isolate",{"label":18,"type":14,"description":11,"interventionNames":19},"High animal protein whole food",[20],"Other: High animal protein whole food",{"label":22,"type":14,"description":11,"interventionNames":23},"High plant protein isolate",[24],"Other: High plant protein isolate",{"label":26,"type":14,"description":11,"interventionNames":27},"High plant protein whole food",[28],"Other: High plant protein whole food",[30,33,36,39],{"type":6,"name":13,"description":31,"armGroupLabels":32,"otherNames":11},"Increased dietary protein content from animal protein isolates",[13],{"type":6,"name":18,"description":34,"armGroupLabels":35,"otherNames":11},"Increased dietary protein content from animal protein whole food",[18],{"type":6,"name":22,"description":37,"armGroupLabels":38,"otherNames":11},"Increased dietary protein content from plant protein isolates",[22],{"type":6,"name":26,"description":34,"armGroupLabels":40,"otherNames":11},[26],[42],{"name":43,"affiliation":5,"role":44},"Bettina Mittendorfer","PRINCIPAL_INVESTIGATOR",[46],{"name":47,"role":48,"phone":49,"phoneExt":11,"email":50},"BETTINA MITTENDORFER","CONTACT","618-610-3465","b.mittendorfer@missouri.edu",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"University of Missouri School of Medicine","RECRUITING","Columbia","Missouri","65212","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-92.33407,38.95171,{"lat":64,"lon":63},[67,68],{"name":47,"role":48,"phone":49,"phoneExt":11,"email":50},{"name":11,"role":48,"phone":11,"phoneExt":69,"email":50},"MITTENDORFER",{"type":44,"investigatorFullName":43,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Senior Associate Dean for Research","100362068",false,"NCT03994367","Animal and Plant Proteins and Glucose Metabolism","HP","Inclusion Criteria:\n\n* age: ≥21 and ≤70 years;\n* BMI: \\>24.5 and \\\u003C32.5 kg\u002Fm2;\n* habitual protein intake \\\u003C0.9 g\u002Fkg\u002Fday (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and\n* weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise\u002Fweek) for at least 2 months before entering the study.\n\nExclusion Criteria:\n\n* prediabetes or type 2 diabetes;\n* evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \\\u003C60 ml\u002Fmin\u002F1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg\u002Fg);\n* vegetarians or vegans;\n* intolerance or allergies to ingredients in the metabolic meal or intervention diet;\n* take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;\n* received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;\n* consume tobacco products or excessive alcohol (women: \\>14 drinks\u002Fweek; men: \\>21 drinks\u002Fweek);\n* evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and\n* unwilling or unable to provide informed consent.",true,"ALL","21 Years","70 Years",{"count":83,"type":84},100,"ESTIMATED","INTERVENTIONAL",[87],"NA","The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.",[90,91,92],"Metabolic Syndrome","Metabolic Syndrome, Protection Against","Glucose Metabolism Disorders",[94,95,96],"High Protein","Metabolism","Diet","2026-05-05",{"date":99,"type":100},"2026-05-08","ACTUAL",{"date":102,"type":100},"2019-07-12",{"date":104,"type":84},"2028-04-25",{"name":5,"class":6},1]