[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644596":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":54,"collaborators":26,"id":57,"slug":26,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":26,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":34,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Medipol University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bio-C Temp, a Calcium Silicate-Based Bioceramic Intracanal Medicament","EXPERIMENTAL","Intervention: Participants in this group receive Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, after standardized chemomechanical root canal preparation and passive ultrasonic irrigation. The medicament is placed into the root canals 1-2 mm short of the working length, and the access cavity is temporarily sealed for 14 days.",[13],"Procedure: Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament",{"label":15,"type":16,"description":17,"interventionNames":18},"UltraCal XS, a Calcium Hydroxide-Based Intracanal Medicament","ACTIVE_COMPARATOR","Intervention: Participants in this group receive UltraCal XS, a calcium hydroxide-based intracanal medicament, after the same standardized chemomechanical root canal preparation and passive ultrasonic irrigation protocol. The medicament is placed into the root canals 1-2 mm short of the working length, and the access cavity is temporarily sealed for 14 days.",[19],"Procedure: Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament","Participants in this group undergo root canal shaping using VDW Rotate heat-treated nickel-titanium rotary files, and root canal preparation is completed up to #35\u002F.04. The irrigation protocol includes 2.5% sodium hypochlorite (NaOCl) and 17% EDTA, followed by passive ultrasonic irrigation (PUI) using a VDW Ultra device with an IRRI S 21\u002F25 ultrasonic tip. After chemomechanical preparation and microbiological sampling, Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, is placed into the root canals 1-2 mm short of the working length. The access cavity is temporarily sealed, and the medicament is left in place for 14 days.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament","Participants in this group undergo the same standardized root canal shaping and irrigation protocol as the Bio-C Temp group. Root canal shaping is performed using VDW Rotate heat-treated nickel-titanium rotary files and completed up to #35\u002F.04. The irrigation protocol includes 2.5% sodium hypochlorite (NaOCl), 17% EDTA, and passive ultrasonic irrigation (PUI) with a VDW Ultra device and an IRRI S 21\u002F25 ultrasonic tip. After chemomechanical preparation and microbiological sampling, UltraCal XS, a calcium hydroxide-based intracanal medicament, is placed into the root canals 1-2 mm short of the working length. The access cavity is temporarily sealed, and the medicament is left in place for 14 days.",[15],[32],{"facility":33,"status":34,"city":35,"state":35,"zip":36,"country":37,"countryCode":26,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Istanbul Medipol University","RECRUITING","Istanbul","34230","Turkey (Türkiye)",{"type":39,"coordinates":40},"Point",[41,42],28.94966,41.01384,{"lat":42,"lon":41},[45,50],{"name":46,"role":47,"phone":48,"phoneExt":26,"email":49},"Berke Turgut","CONTACT","+905312267156","dtberketurgut@gmail.com",{"name":51,"role":47,"phone":52,"phoneExt":26,"email":53},"Tan Fırat Eyüboğlu","+905304636059","tfeyuboglu@yahoo.com",{"type":55,"investigatorFullName":46,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Director, Clinical Research","100644596",false,"NCT07671326","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide-Based Intracanal Medicaments in Endodontic Treatment","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Being systemically healthy (ASA I or ASA II)\n* Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region\n* Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form\n\nExclusion Criteria:\n\n* Patients who have received antibiotics or corticosteroids within the last 3 months\n* Patients with systemic diseases\n* Teeth that cannot be properly isolated with a rubber dam\n* Teeth with periodontal pockets \\>4 mm and teeth with crown\u002Froot fractures\n* Individuals who are undergoing or planning to start orthodontic treatment during the study period\n* Pregnant or breastfeeding individuals",true,"ALL","18 Years","65 Years",{"count":68,"type":69},24,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis. Intracanal bacterial load is assessed before and after root canal preparation, after intracanal medicament removal, and after final irrigation using droplet digital PCR.",[75,76,77],"Periapical Periodontitis","Root Canal Infection","Intracanal Medicaments",[79,80,81,82],"intracanal medicament","bioceramic medicament","ultrasonic activation","ddPCR","2026-06-25",{"date":85,"type":86},"2026-06-29","ACTUAL",{"date":88,"type":86},"2025-10-15",{"date":90,"type":69},"2026-12",{"name":5,"class":6},1]