[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636189":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":63,"collaborators":65,"id":69,"slug":31,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":31,"eligibilityCriteria":73,"healthyVolunteers":70,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":31,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":90,"whyStopped":31,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Emory University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Music Therapy group","EXPERIMENTAL","The MT group will engage in 20-minute daily virtual music therapy sessions for 4 weeks, using the freely available Music Care© app (manufactured by MUSIC CARE) to independently participate in electronic music therapy following the U sequence. This app is voluntarily downloaded onto a participant's personal device, and participants will be instructed to complete daily MT sessions under optimal conditions (i.e., lying down, eyes closed, low lighting).",[13],"Other: Music Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","SHAM_COMPARATOR","The control group will be asked to engage with educational material for 20 minutes daily. There will be no restrictions for research subjects in regards to listening to music under other conditions (e.g., phone, radio, concert, etc)",[19],"Other: Standard of Care",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Music Therapy","The MT group will engage in 20-minute daily virtual music therapy sessions for 4 weeks, using the freely available Music Care© app (manufactured by MUSIC CARE) to independently participate in electronic music therapy following the U sequence. This app is voluntarily downloaded onto a participants personal device and participants will be instructed to complete daily MT sessions under optimal conditions (i.e., lying down, eyes closed, low lighting).",[9],[26],"MT",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Standard of Care","Routinely available educational material on sickle cell disease management and a healthy lifestyle.",[15],null,[33],{"name":34,"affiliation":5,"role":35},"Manoj Bhasin","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":31,"email":41},"Manoj Bhasin, PhD","CONTACT","404-712-9849","manoj.bhasin@emory.edu",[43],{"facility":44,"status":31,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Children's Healthcare of Atlanta","Atlanta","Georgia","30324","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-84.38798,33.749,{"lat":54,"lon":53},[57,61],{"name":58,"role":39,"phone":59,"phoneExt":31,"email":60},"Soumitri Sil, PhD","404-727-2712","soumitri.sil@emory.edu",{"name":58,"role":62,"phone":31,"phoneExt":31,"email":31},"SUB_INVESTIGATOR",{"type":35,"investigatorFullName":34,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Professor",[66],{"name":67,"class":68},"National Institutes of Health (NIH)","NIH","100636189",false,"NCT07562451","Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing","Inclusion Criteria:\n\n* Diagnosed with SCD\n* English fluency (for survey completion)\n* Have access to a personal electronic device (e.g., phone, tablet) with access to the internet\n* Meet the criteria for chronic pain defined by the International Association for the Study of Pain (IASP). IASP defines chronic pain as pain that is both:\n\n  1. Persistent or recurrent for ≥ 3 months\n  2. is associated with significant emotional distress or functional disability.30\n\nExclusion Criteria:\n\n* Major hearing deficiency or medical condition in which listening to music may be contraindicated (e.g., reflex epilepsy).","ALL","8 Years","18 Years",{"count":78,"type":79},25,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD).\n\nThe main questions it aims to answer are:\n\n* Does MT reduce pain intensity, frequency of pain episodes, and improve health-related quality of life (HRQoL)?\n* Does MT alter immune cell composition and gene expression in inflammatory pathways, as measured by single-cell RNA sequencing (scRNA-seq)?\n\nResearchers will compare participants randomized to music therapy versus a control condition to see if MT produces superior improvements in pain and psychosocial outcomes, and distinct molecular changes.",[85],"Sickle Cell Disease",[87,88,89],"Music therapy","Pain control","Sickle cell disease","NOT_YET_RECRUITING","2026-06-29",{"date":93,"type":94},"2026-07-01","ACTUAL",{"date":96,"type":79},"2026-07",{"date":98,"type":79},"2028-04",{"name":5,"class":6},1]