Assessment of Pulmonary Function in Relation to the Anesthetic Used in Patients Undergoing Bariatric Surgery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMedical University of Gdansk
About this trial
It is known that more or less pronounced impairment of pulmonary function occurs after anesthesia. It has been demonstrated in the postoperative period in both patients undergoing general and regional anesthesia, in patients after intra-abdominal and superficial procedures, in overweight and normal-weight patients. It has also been shown that when general anesthesia is performed with the inhalation anesthetic sevoflurane, there is a slightly smaller reduction in lung function parameters than when only intravenous anesthetics are used.
The purpose of this study is to evaluate lung function before induction and after awakening from general anesthesia depending on the inhalational anesthetic used in obese patients undergoing bariatric surgery
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Obese patients qualified for bariatric surgery.
Disqualifiers
with aneurysms of the aorta or cerebral arteries threatening to rupture, after recent vascular surgery
with increased intracranial pressure, after recent intracranial bleeding or head surgery within the cranial cavity
after acute conditions within 6 months prior to surgery such as stroke, myocardial infarction, unstable angina, pneumothorax
with uncontrolled hypertension
Trial design
Design model
Parallel
Treatments tested in this trial
Different drug type for conduction of general anesthesia
DrugPatients will be randomly divided into two groups: patients for whom general anesthesia will be performed with sevoflurane and patients for whom general anesthesia will be performed with desflurane.
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: General anesthesia with desfluraneExperimental treatment 1 intervention
Group B: General anesthesia with sevofluraneExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Heart rate (HR)
HR will be measured by ecg in beat per minute
Time frame
Continuously during whole duration of anesthesia2
Pulse oximetry (SpO2)
SpO2 will be measured by light spectrometry percutaneous sensor in %
Time frame
Continuously during whole duration of anesthesia3
End tidal CO2 (etCO2)
etCO2 will be measured by capnography with infrared radiation sensor in mmHg. Sensor will be attached to breathing circuit.
Time frame
Continuously during whole duration of anesthesia4
Minimum alveolar concentration (MAC)
MAC will be measured based on exhaled anesthetic gas concentration in absolute numbers
Time frame
Continuously during whole duration of anesthesiaSponsors and contacts
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Source ClinicalTrials.gov