Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.
Female participants aged 18 years or older
Clinically diagnosed lipedema according to established diagnostic criteria
Ability to provide written informed consent
Ability to complete clinical assessments and questionnaires
History of lower extremity venous surgery or sclerotherapy
Known peripheral arterial disease
Secondary lymphedema or other causes of lower extremity edema
Active infection, cellulitis, or inflammatory disease affecting the lower extremities