[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580701":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":44,"collaborators":10,"id":48,"slug":10,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Guangzhou Institute of Respiratory Disease","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Case group",null,"Diagnosis of asthma children",{"label":13,"type":10,"description":14,"interventionNames":10},"Control group","Physical health of children",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Lihong Sun, M.D.","CONTACT","13719240285","sunlihong9797@126.com",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Lanying Cheng","15918742726","chenglanyingmed@163.com",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Guangzhou institute of respiratory disease","RECRUITING","Guangzhou","Guangdong","510120","China","CN",{"type":35,"coordinates":36},"Point",[37,38],113.25,23.11667,{"lat":38,"lon":37},[41],{"name":42,"role":18,"phone":43,"phoneExt":10,"email":20},"Lihong Sun, master","+86-13719240285",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","LI-HONG SUN","Professor","100580701",false,"NCT06840717","Association Between Genetic Polymorphisms and Type 2 Asthma in Children","Association Between Cytokines Gene Single Nucleotide Polymorphisms and Type 2 Inflammatory Asthma in Children","SNP","Inclusion Criteria:\n\n1. All children with asthma diagnosis accord with the GINA in 2023 edition;\n2. Other diseases that could cause wheezing and cough were excluded, such as acute laryngitis, diphtheria, congenital airway abnormalities, and tracheal foreign bodies;\n3. In front of the hospital 2 weeks without antibiotics, systemic hormone medication history;\n4. There were no other complications, such as congenital heart disease, pneumonia, gastroesophageal reflux disease, muscle dysplasia, etc.\n\nExclusion Criteria:\n\n1. Children who had taken immunosuppressants, antibiotics and other drugs for a long time before admission;\n2. Children with primary immunodeficiency disease;\n3. The children and their families failed to cooperate or refused the experimental observation.",true,"ALL","3 Years","14 Years",{"count":60,"type":61},300,"ESTIMATED","1 Year","OBSERVATIONAL","To further understand the role of gene single nucleotide polymorphism (SNP) in the occurrence of type 2 inflammation-related asthma in children by analyzing the gene single nucleotide polymorphism (SNP), lung function and type 2 inflammation indicators of children diagnosed with asthma in outpatient and inpatient. To provide a theoretical basis for the study of personalized treatment and prevention strategies for asthma.",[66,67,68],"Asthma in Children","Genetic Disease","Inflammation",[70,71,72,73,74],"cytokines","Single nucleotide polymorphism","type 2 inflammation","ashtma","Susceptibility","2025-02-18",{"date":77,"type":78},"2025-02-21","ACTUAL",{"date":80,"type":78},"2024-01-30",{"date":82,"type":61},"2025-12-30",{"name":5,"class":6},1]