Autologous Platelet Concentrates on the Healing of Extraction Sockets
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25+
SponsorQueen Mary University of London
About this trial
This study will evaluate the effect of A-PRF, a second-generation APC, on early wound healing in high-risk MRONJ patients following dental extractions, utilising advanced non-invasive methods to assess and associate molecular and blood flow changes during early healing. The early healing events of the post-extraction socket will also be characterised in terms of volumetric changes in relation to intra-oral thermographic changes, blood flow changes, in tandem with clinical measures of soft tissue healing and post-operative pain assessment. The early healing events will be analysed up to 15 days, and the final recall will be 180 days after extraction.
Eligibility criteria
Qualifiers
Patient must be willing to read and sign a copy of the Informed Consent Form
Males and females ≥ 25 years old;
Patients who are currently or previously treated with antiresorptive therapy alone or in combination with immune modulators or antiangiogenic medications for the management of cancer;
Patients who are treated with antiresorptive therapy, bisphosphonates, for osteoporosis for more than 5 years;
Disqualifiers
None
Trial design
Treatments tested in this trial
- Application of A-PRF into extraction socket
Treatment groups
44 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov