Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical CVK-related thrombosis (Rockholt et al.). To shed light on this problem, the current studies were designed. In sub-study 1, deceased patients with CVC who are referred for clinical autopsy are included. Before the autopsy, the deceased will be examined with a photon-counting computed tomography (CT) scan and the results will be compared.
In sub-study 2, living patients with CVC who are referred for various CT scans without contrast, are included. After informed consent, the patient will be examined with the photon-counting CT, whose reliability has been validated in Part 1 and the incidence of subclinical CVC-related thrombosis will be reported.
Diseased patients with an indwelling central venous catheter and a clinical indication for autopsy
Informed and signed consent from next of kind
None
Living patients with an indwelling central venous catheter who are referred to a CT scan without iv contrast
Informed and signed consent from the patient
Substudy 1: Diseased patients with an indwelling central venous catheter and a clinical indication for autopsy Substudy 2: Living patients with an indwelling central venous catheter who are referred to a CT scan without iv contrast
Cohort
Prospective
Diseased patients with an indwelling central venous catheter who is referred to autopsy
Diagnostic testPhoton counting CT is performed and the results are compared to the results of the autopsy
Living patients with an indwelling central venous catheter referred to a CT scan without iv contrast
RadiationPatients will be investigated using a photon counting CT. Prior to the investigation patients will be investigated with ultrasound. The results from the two modalities will be compared
The incidence of venous thrombosis related to a central venous catheter in diseased patients
Venous thrombosis related to a central venous catheter detected at autopsy
The performance of the photon counting CT on diseased patients
The performance of the photon counting CT will be evaluated by comparing the findings from the CT with the findings from the autopsy
The incidence of venous thrombosis related to a central venous catheter in living patients
The incidence of venous thrombosis related to a central venous catheter in living patients detected with a photon counting CT
The performance of ultrasound compared to the photon counting CT
The performance of ultrasound compared to the photon counting CT in detecting enous thrombosis related to central venous catheters
Click on the lead sponsor to view all of their trials.
Thomas Kander
Lead sponsor
Region Skane
Sponsor institution
