Avocado and Postprandial Responses

ConditionsHealthy Healthy Volunteer Healthy Volunteers Healthy Adult Healthy Male and Female Subjects Healthy Subjects Healthy Volunteers Only Healthy Non-smokers

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age21-65

SponsorUniversity of Vermont Medical Center

About this trial

The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating.

The investigators will test the effects of 3 breakfast meals on blood sugar control and signals of hunger and fullness after eating:

1. Whole-wheat bread and strawberry jam 2. Whole-wheat bread, strawberry jam, and avocado 3. Whole-wheat bread and strawberry jam (meal enriched with fat and fiber to mimic that of an avocado)

Participants will undergo 3 test periods, each separated by a week. Each test period consists of one day with set meals that the investigators will provide (breakfast, lunch, and dinner), and then the next morning, participants will eat a breakfast meal and have blood drawn several times over 4 hours.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Biological sex males or females

Age 21 to 65 years

BMI between 18.5 and 34.9 kg/m2

Disqualifiers

Actively pregnant or lactating women

Diagnosis of prediabetes or diabetes (fasting glucose >100 mg/dL)

Current diagnosis of uncontrolled hypertension (systolic BP: >160 mmHg, diastolic BP: >95 mmHg), may receive treatment for hypertension as long as on a stable regimen for the previous one month

Current diagnosis of uncontrolled hyperlipidemia (fasting total blood cholesterol >200 mg/dL, fasting triglycerides >200 mg/dL), may receive treatment for hyperlipidemia as long as on a stable regimen for the previous one month

Trial design

Design model

Crossover

Treatments tested in this trial

Negative control
Other intervention
Participants will be given a breakfast meal with 76 grams of bread and 60 grams of jam per 2000 daily calories.
Avocado
Other intervention
Participants will be given a bread and jam breakfast (76 grams of bread and 60 grams of jam per 2000 daily calories) supplemented with 84 grams of avocado per 2000 daily calories.
Fat and fiber addition
Other intervention
Participants will be given a bread and jam breakfast (76 grams of bread and 60 grams of jam per 2000 daily calories) supplemented with 13 grams of fat (mix of high-oleic safflower oil, safflower oil, palm oil, and macadamia nut oil) and 5.5 grams of fiber (mix of cellulose and pectin) per 2000 daily calories.

Treatment groups

30 Participants

are divided into 3 treatment groups

Group A: Negative control breakfastOther 1 intervention

Group B: Avocado addition breakfastExperimental treatment 1 intervention

Group C: Fat and fiber control breakfastActive comparator 1 intervention

Trial outcomes

Primary outcomes

Diet-induced changes in postprandial glucose tolerance

Blood glucose and insulin concentrations will be measured.

Time frame

60-minute time point, 120-minute time point, incremental area under the curve from fasting to 180-minute time point

Secondary outcomes

Diet-induced changes in postprandial satiety hormones

Blood ghrelin, peptide YY, glucagon-like peptide (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), leptin, and adiponectin concentrations will be measured.

Time frame

60-minute time point, 120-minute time point, incremental area under the curve from fasting to 180-minute time point

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Vermont Medical Center

Lead sponsor

Avocado Nutrition Center

Collaborator

Source ClinicalTrials.gov

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