[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634623":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":12,"collaborators":10,"id":16,"slug":10,"hasResults":17,"nctId":18,"briefTitle":19,"officialTitle":20,"acronym":10,"eligibilityCriteria":21,"healthyVolunteers":17,"sex":22,"minAge":23,"maxAge":10,"enrollmentInfo":24,"targetDuration":10,"studyType":27,"phases":10,"briefSummary":28,"conditions":29,"keywords":35,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Mechanically Ventilated Obese Patients",null,"Adult patients with a BMI ≥ 33 kg\u002Fm² requiring invasive mechanical ventilation in the respiratory ICU. All participants in this single-cohort study will undergo a standardized, stepwise pressure-controlled lung recruitment maneuver reaching a peak inspiratory pressure of 35 cmH₂O and a PEEP of 20 cmH₂O. This is immediately followed by a decremental PEEP titration. The primary observational focus is the use of a bedside 12-zone Lung Ultrasound (LUS) scan to monitor real-time regional lung re-aeration, calculate total LUS scores before and after the maneuver, and identify the optimal PEEP based on lung closing pressures.",{"type":13,"investigatorFullName":14,"investigatorTitle":15,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Asmaa Mostafa Hammam","Resident at Chest Diseases Department, Assiut University","100634623",false,"NCT07542093","Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients","Use of Bedside Lung Ultrasound to Monitor Lung Recruitment Maneuvers During Mechanical Ventilation in Obese Patients","Inclusion Criteria:\n\n* Adult patients aged \\>18 years\n* BMI ≥ 33 kg\u002Fm² (morbid obesity)\n* Intubated and receiving invasive mechanical ventilation for any indication (elective surgery, respiratory failure, post-operative ICU admission)\n* Expected duration of mechanical ventilation ≥ 6 hours\n* Hemodynamically stable at enrollment: Mean Arterial Pressure (MAP) ≥ 65 mmHg without escalating vasopressor support\n* SpO₂ ≥ 85% on current ventilator settings\n* Written informed consent obtained from patient or legal guardian\n\nExclusion Criteria:\n\n* Known or suspected pneumothorax or bullous emphysema (contraindication to recruitment maneuvers)\n* Severe hemodynamic instability: MAP \\\u003C 60 mmHg or requiring high-dose vasopressors (norepinephrine \\> 0.3 mcg\u002Fkg\u002Fmin)\n* Active bronchopleural fistula\n* Recent thoracic or cardiac surgery (within 48 hours) where high airway pressures are contraindicated\n* Raised intracranial pressure (ICP) or known severe traumatic brain injury\n* Confirmed ARDS with PaO₂\u002FFiO₂ ratio \\\u003C 100 mmHg (severe ARDS, where recruitment strategy differs significantly)\n* Chest wall deformity or subcutaneous emphysema that precludes reliable lung ultrasound assessment\n* Refusal of consent","ALL","18 Years",{"count":25,"type":26},45,"ESTIMATED","OBSERVATIONAL","Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse. This happens because the extra weight of the chest and abdomen presses on the lungs, reducing their capacity and making it difficult to maintain adequate oxygen levels. To address this, doctors often perform a standard lung recruitment maneuver, which involves temporarily increasing the air pressure from the ventilator to gently pop open the collapsed lung areas. However, standard bedside monitoring tools make it difficult to see exactly how well the different regions of the lungs are reopening.\n\nThis prospective observational study aims to evaluate the use of Bedside Lung Ultrasound (LUS), which is a safe, radiation-free imaging tool, to monitor how well the lungs respond to these maneuvers in real-time.\n\nDuring the study, researchers will use a standardized 12-zone ultrasound scan to examine the lungs of mechanically ventilated adult patients (BMI ≥ 33 kg\u002Fm²) before, during, and after a step-by-step lung recruitment maneuver. By calculating a \"Total Lung Ultrasound Score,\" the medical team can directly visualize and measure the transition from collapsed tissue to normal, aerated lung tissue. Furthermore, the ultrasound will be used during a step-down pressure phase to help identify the patient's \"optimal PEEP\" (Positive End-Expiratory Pressure), which is the exact customized pressure needed to keep the lungs open after the maneuver is complete, thereby improving oxygenation and minimizing the risk of lung injury.",[30,31,32,33,34],"Morbid Obesity","Obesity","Respiratory Failure","Atelectasis","Ventilator-Induced Lung Injury (VILI)",[36,37,38,39,40,41,42],"Lung Ultrasound (LUS)","Lung Ultrasound Score","Lung Recruitment Maneuvers (LRM)","Mechanical Ventilation","Positive End-Expiratory Pressure (PEEP)","Optimal PEEP","Decremental PEEP Titration","NOT_YET_RECRUITING","2026-04-14",{"date":46,"type":47},"2026-04-21","ACTUAL",{"date":49,"type":26},"2026-05",{"date":51,"type":26},"2027-06",{"name":5,"class":6}]