[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100452656":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":28,"responsibleParty":46,"collaborators":18,"id":49,"slug":18,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":18,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":31,"whyStopped":18,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"UConn Health","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HFpEF patients","EXPERIMENTAL","HFpEF patient who are currently taking beta blockers",[13],"Other: beta blocker discontinuation",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":18},"beta blocker discontinuation",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Kai Chen, MD,PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},"CONTACT","860-679-3343","kachen@uchc.edu",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"UConn Health \u002F John Dempsey Hospital","RECRUITING","Farmington","Connecticut","06030","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-72.83204,41.71982,{"lat":41,"lon":40},[44],{"name":45,"role":25,"phone":26,"phoneExt":18,"email":27},"Kai Chen, MD, PhD",{"type":22,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Christopher Pickett","Associate Professor","100452656",false,"NCT05174351","Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction","Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction","HFpEF-BB","Inclusion Criteria:\n\n* Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100\n* N=30 (Target: 30).\n* Age: 50 \\~ 80 years.\n* ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.\n* Chronic loop diuretic use\n* Currently on beta-blocker\n\nExclusion Criteria:\n\n* Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.\n* Heart rate \\> 100 bpm\n* Recent hospitalization due to HF within 3 months\n* Non-English speaker","ALL","50 Years","80 Years",{"count":60,"type":61},30,"ESTIMATED","INTERVENTIONAL",[64],"NA","This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.",[67],"Heart Failure With Preserved Ejection Fraction",[69,70,71,72],"HFpEF","Beta-blocker","echocardiogram","6MWT","2025-09-23",{"date":75,"type":76},"2025-09-29","ACTUAL",{"date":78,"type":76},"2021-12-20",{"date":80,"type":61},"2027-11-01",{"name":5,"class":6},1]