[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644449":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":22,"centralContacts":22,"locations":22,"responsibleParty":35,"collaborators":22,"id":39,"slug":22,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":22,"eligibilityCriteria":43,"healthyVolunteers":40,"sex":44,"minAge":45,"maxAge":22,"enrollmentInfo":46,"targetDuration":22,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":22,"overallStatus":55,"whyStopped":22,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":22},{"fullName":5,"class":6},"Elisabethinen Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"dialysate composition adjustment","EXPERIMENTAL","Four sequential 3-week treatment periods with different dialysate compositions (D-Standard, D-Bic, D-Mag, D-BicMag) in a crossover design.",[13,14,15,16],"Other: D-Standard","Other: D-Bic","Other: D-Mag","Other: D-BicMag",[18,23,27,31],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"D-Standard","Center's standard dialysate containing 32 mmol\u002FL bicarbonate and 0.5 mmol\u002FL magnesium",[9],null,{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"D-Bic","Dialysate bicarbonate increased to 37 mmol\u002FL; dialysate magnesium held at 0.5 mmol\u002FL",[9],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"D-Mag","Dialysate magnesium increased to 1.0 mmol\u002FL; dialysate bicarbonate held at 32 mmol\u002FL",[9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"D-BicMag","Dialysate bicarbonate increased to 37 mmol\u002FL; dialysate magnesium increased to 1.0 mmol\u002FL",[9],{"type":36,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Prim. Priv. Doz. Dr. Daniel Cejka","Head of Nephrology","100644449",false,"NCT07663279","BicMag Study - Improving Mineral Buffering Capacity in Dialysis Patients","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Prevalent patients (≥ 3 months) treated with thrice weekly hemodialysis or hemodiafiltration\n* Dialysate calcium of 1.25 mmol\u002Fl\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Currently participating in another investigational device or drug study or non-interventional study\n* Dialysate calcium other than 1.25 mmol\u002Fl\n* Parathyroidectomy planned during the study\n* Elective living-donor kidney transplant scheduled during the study period\n* Therapy with bisphosphonates within the past 12 months or denosumab within the past 6 months\n* Pregnant or nursing (lactating) women","ALL","18 Years",{"count":47,"type":48},91,"ESTIMATED","INTERVENTIONAL",[51],"NA","The BicMag study is a prospective, randomized, controlled cross-over study that aims to examine the potential additive effect of a dialysate enriched with both bicarbonate and magnesium on mineral buffering capacity in the blood of chronic hemodialysis patients.",[54],"End Stage Renal Disease","NOT_YET_RECRUITING","2026-06-17",{"date":58,"type":59},"2026-06-23","ACTUAL",{"date":61,"type":48},"2026-10",{"date":63,"type":48},"2029-12",{"name":5,"class":6}]