This trial collects and analyzes sweat and saliva samples compared to blood in detecting chemical concentrations in the body in patients with chronic or infectious diseases receiving medications. Wearable sweat sensors are capable of monitoring electrolytes and metabolites (sodium, potassium, glucose, lactate, etc.) for health monitoring and disease diagnosis. Designing wearable sweat sensors capable of providing information regarding drug administration may be challenging due to ultralow concentrations in biofluids. This trial seeks to determine if the use of a smart wristband can accurately measure the levels of chemicals and substances in sweat.
Scheduled to receive medications including, but not limited to, cyclophosphamide, mycophenolic acid, mycophenolate mofetil, metformin or busulfan (any dose, any number of doses, any dosing frequency) as part of treatment at any time. Patients with chronic or infectious diseases can participate
Provide blood, sweat, and saliva samples
Permit medical record review
Pilocarpine allergy
Difficulty with understanding written English
Patients with chronic or infectious diseases scheduled to receive medications
Cohort
Prospective
Biospecimen Collection
Procedure/SurgeryUndergo collection of sweat, saliva, and blood samples
Medical Chart Review
Other interventionReview of medical chart
Questionnaire Administration
Other interventionComplete questionnaire
Predictive performance of the home-based sampling
Will be assessed by Pearson correlation and quantification of the predictive performance. The predictive performance of the home-based sampling methods will be assessed by calculating the median percentage prediction error (MPPE).
Observed plasma concentrations
Will be assessed by Pearson correlation and quantification of the predictive performance. The values from plasma will be considered the observed concentration.
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City of Hope Medical Center
Lead sponsor
National Cancer Institute (NCI)
Collaborator
