[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638384":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":21,"locations":26,"responsibleParty":42,"collaborators":7,"id":46,"slug":7,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":7,"studyType":59,"phases":7,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":76,"whyStopped":7,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Kyrenia","OTHER",null,[9,12,15,18],{"name":10,"affiliation":5,"role":11},"Utku Gurhan, MD","PRINCIPAL_INVESTIGATOR",{"name":13,"affiliation":5,"role":14},"Fazli Levent Umur, MD","SUB_INVESTIGATOR",{"name":16,"affiliation":17,"role":14},"Enes Sari, MD","Near East University",{"name":19,"affiliation":20,"role":14},"Yakup Kahve, MD","Ankara City Hospital Bilkent",[22],{"name":10,"role":23,"phone":24,"phoneExt":7,"email":25},"CONTACT","+90 539 112 6898","utkugrhn@gmail.com",[27],{"facility":28,"status":7,"city":29,"state":7,"zip":7,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"University of Kyrenia, Dr. Suat Gunsel Hospital - Department of Orthopaedics and Traumatology","Kyrenia","Cyprus","CY",{"type":33,"coordinates":34},"Point",[35,36],33.31729,35.33634,{"lat":36,"lon":35},[39,40,41],{"name":10,"role":23,"phone":7,"phoneExt":7,"email":25},{"name":10,"role":11,"phone":7,"phoneExt":7,"email":7},{"name":13,"role":14,"phone":7,"phoneExt":7,"email":7},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","Utku Gürhan","Assistant Professor of Orthopaedics and Traumatology","100638384",false,"NCT07617233","Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis","Baseline Neutrophil-to-Lymphocyte Ratio and Related Complete Blood Count-Derived Inflammatory Indices as Predictors of Clinical Response to Intra-Articular Platelet-Rich Plasma in Knee Osteoarthritis: A Prospective Single-Arm Cohort Study","PRP-NLR","Inclusion Criteria:\n\n* Age 40 to 60 years\n* Symptomatic primary knee osteoarthritis, Kellgren-Lawrence grade 2 or 3 on weight-bearing radiographs\n* Body mass index below 40\n* Candidate for and scheduled to receive a course of intra-articular platelet-rich plasma for the index knee\n* Able and willing to provide written informed consent and to attend the 6-month follow-up schedule\n\nExclusion Criteria:\n\n* Systemic inflammatory or autoimmune disease\n* Active acute infection at the time of enrollment\n* Current anticoagulant or antiplatelet therapy, or current or recent chemotherapy\n* Any contraindication to platelet-rich plasma per the 2025 GRIIP recommendations\n* Intra-articular injection of the index knee within the previous 6 months\n* Inability to comply with the planned follow-up schedule","ALL","40 Years","60 Years",{"count":57,"type":58},120,"ESTIMATED","OBSERVATIONAL","Intra-articular platelet-rich plasma (PRP) injection is a widely used treatment for knee osteoarthritis, but patients respond to it very differently and there is currently no simple, inexpensive way to predict who will benefit. The neutrophil-to-lymphocyte ratio (NLR) and related indices derived from a routine complete blood count reflect a person's baseline inflammatory state. This prospective single-arm observational cohort study investigates whether the baseline NLR, together with the platelet-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII), and the monocyte-to-lymphocyte ratio (MLR), predicts the clinical response to intra-articular PRP in patients with Kellgren-Lawrence grade 2 to 3 knee osteoarthritis. The investigators will enroll 120 patients aged 40 to 60 years, each of whom receives a standardized course of three leukocyte-poor PRP injections one week apart. Patients are followed for 6 months, and the primary clinical outcome is the change in the WOMAC osteoarthritis index at 6 months. Outcome assessors are blinded to patients' blood-count values. If a baseline blood ratio predicts response, it could become a low-cost tool to guide patient selection for PRP.",[62,63],"Knee Osteoarthritis","Osteoarthritis",[65,66,67,68,69,70,71,72,73,74,75],"platelet-rich plasma","PRP","knee osteoarthritis","neutrophil-to-lymphocyte ratio","NLR","systemic immune-inflammation index","biomarker","predictor","intra-articular injection","WOMAC","inflammatory index","NOT_YET_RECRUITING","2026-06-18",{"date":79,"type":80},"2026-06-23","ACTUAL",{"date":82,"type":58},"2026-09",{"date":84,"type":58},"2027-07",{"name":44,"class":6},1]