Blood Storage Related Mortality and Adverse Effects in Trauma Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorKocaeli City Hospital
About this trial
The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions:
1. The effect of blood storage time on the patient's 28-day mortality rate. 2. The relationship between storage time and other health problems that the patient may develop (such as heart disease, vascular occlusion, respiratory failure, infection, and organ failure).
For this purpose, patients aged 18-75 who were admitted directly from the scene of injury and received large transfusions at Jacksonville Shands Hospital between January 1, 2023, and October 1, 2025, will be included. Data will be obtained from hospital information systems and anesthesia records
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients between 18-75 years of age,
Injury Severity Score>15 and have received massive blood transfusions in our hospital from 1 January 2015 to 31 December 2025
The patients admitted because of trauma and undergoing surgery
Disqualifiers
Patients with known cardiac or vascular diseases such as heart failure or malignant hypertension, those under anticoagulant treatment
Patients with known serious kidney (on dialysis), lung, liver diseases, those under anticoagulant treatment
Super obese patients with body mass index (BMI) 50 or above
Trial population
In our study, patients between the ages of 18-75, directly from the scene of injury, ISS\>15 and who received massive blood transfusion (\>10 packed RBC units in the first 24 hours, with an alternative definition of greater than or equal to 3 packed RBC units transfused in 1 hour) will be included in the study at University of Florida Jacksonville Shands Hospital between the dates 1 January 2023 to 1 31 December 2025.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
300 Participants
are grouped into 1 trial groupGroup A: Group 1
Trial outcomes
Primary outcomes
1
28-day Mortality
The aim of this study was to evaluate the effect of red blood cell and whole blood storage duration on 28-day mortality in severely injured trauma patients (injury severity score \>15) undergoing massive transfusion.
Time frame
At the day of 28 after massive blood transfusionSecondary outcomes
1
28-day Morbidity - Cardiac Ischemia
On the 28th day after the blood transfusion, patients will be assessed for cardiac ischemia.
Time frame
At the day of 28 after massive blood transfusion2
28-day morbidity- thromboembolic events
On the 28th day after the blood transfusion, patients will be assessed for thromboembolic events,
Time frame
At the day of 28 after massive blood transfusion3
28-day morbidity- nosocomial infection
On the 28th day after the blood transfusion, patients will be assessed for nosocomial infection,
Time frame
At the day of 28 after massive blood transfusion4
28-day morbidity- multiple organ failure
On the 28th day after the blood transfusion, patients will be assessed for multiple organ failure.
Time frame
At the day of 28 after massive blood transfusionSponsors and contacts
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Source ClinicalTrials.gov