[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611603":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":66,"collaborators":42,"id":69,"slug":42,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":42,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":50,"whyStopped":42,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Federal University of São Paulo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bone Marrow Aspirate (BMA) Group","EXPERIMENTAL","Participants receive a single ultrasound-guided injection of autologous bone marrow aspirate (approximately 8 mL) into\u002Faround the plantar fascia on one side, according to randomization.\n\nBone marrow aspirate is obtained from the posterosuperior iliac crest under local anesthesia and prepared under sterile conditions. The injection is performed after regional anesthesia of the tibial nerve using ultrasound guidance.",[13],"Biological: Bone Marrow Aspirate Injection",{"label":15,"type":10,"description":16,"interventionNames":17},"Platelet-Rich Fibrin (PRF) Group","Participants receive a single ultrasound-guided injection of autologous platelet-rich fibrin (PRF, approximately 8 mL) into\u002Faround the plantar fascia on the contralateral side, according to randomization.\n\nPRF is prepared from 60 mL of venous blood centrifuged without anticoagulant to form a fibrin clot, which is injected into the painful area of the fascia after regional anesthesia of the tibial nerve under ultrasound guidance.",[18],"Biological: Platelet-Rich Fibrin Injection",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","Bone Marrow Aspirate Injection","Ultrasound-guided injection of autologous bone marrow aspirate obtained from the posterosuperior iliac crest under local anesthesia. Approximately 8mL of aspirate is injected into\u002Faround the plantar fascia.",[9],[26],"BMA",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Platelet-Rich Fibrin Injection","Ultrasound-guided injection of autologous platelet-rich fibrin (PRF) prepared from 60 mL of venous blood centrifuged to form a fibrin clot. Approximately 8mL of PRF is injected into\u002Faround the plantar fascia.",[15],[32],"PRF",[34],{"name":35,"affiliation":5,"role":36},"Lucas Fonseca","PRINCIPAL_INVESTIGATOR",[38,44],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"LUCAS FONSECA, MD","CONTACT","+5511982148662",null,"contato@drlucasfonseca.med.br",{"name":45,"role":40,"phone":42,"phoneExt":42,"email":46},"Carlos Franciozi, PhD","cacarlos66@hotmail.com",[48],{"facility":49,"status":50,"city":51,"state":42,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Federal University of São Paulo - Hospital São Paulo","RECRUITING","São Paulo","04023-900","Brazil","BR",{"type":56,"coordinates":57},"Point",[58,59],-46.63611,-23.5475,{"lat":59,"lon":58},[62,65],{"name":63,"role":40,"phone":64,"phoneExt":42,"email":43},"Lucas Fonseca, MD","+55 11 98214-8662",{"name":63,"role":36,"phone":42,"phoneExt":42,"email":42},{"type":36,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Rodrigo de Almeida Mastrorosa","Principal Investigator \u002F PhD Candidate","100611603",false,"NCT07242729","Bone Marrow Aspirate Versus Platelet-Rich Fibrin for the Treatment of Chronic Plantar Fasciitis","Bone Marrow Aspirate Versus Platelet-Rich Fibrin for the Treatment of Plantar Fasciitis - A Double-Blind Randomized Clinical Trial","fasciitis","Inclusion Criteria:\n\n* Adults aged 18 to 75 years.\n* Clinical diagnosis of chronic plantar fasciitis for more than 6 months, confirmed by ultrasonography (increased plantar fascia thickness and hypoechogenicity).\n* Persistent heel pain refractory to conventional conservative treatment (stretching, orthotics, physical therapy, or corticosteroid injections).\n* Visual Analog Scale (VAS) pain score ≥ 4 at baseline.\n* Ability and willingness to comply with study procedures and follow-up assessments.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Previous foot or ankle surgery on the affected limb.\n* Acute trauma, infection, or ulceration in the region of the plantar fascia.\n* Systemic inflammatory diseases (e.g., rheumatoid arthritis, lupus, psoriatic arthritis).\n* Metabolic or endocrine disorders interfering with healing (e.g., diabetes mellitus with poor glycemic control, thyroid disorders).\n* Current use of systemic corticosteroids, immunosuppressants, or anticoagulants.\n* Active neoplasia or hematologic disorders.\n* Pregnancy or breastfeeding.\n* Peripheral vascular disease or neuropathy affecting the lower limbs.\n* Contraindications to local anesthesia or venipuncture.","ALL","18 Years","75 Years",{"count":80,"type":81},72,"ESTIMATED","INTERVENTIONAL",[84],"NA","This randomized, double-blind clinical trial aims to compare the clinical and imaging effects of autologous bone marrow aspirate versus platelet-rich fibrin injections in patients with chronic plantar fasciitis. The procedures are performed under ultrasound guidance to ensure precision and safety. The study evaluates pain reduction, foot function, and ultrasonographic changes in the plantar fascia at follow-up intervals.",[87],"Plantar Fasciitis",[89],"Plantar Fasciitis; Bone Marrow Aspirate; Platelet-Rich Fibrin; Ultrasound-Guided Injection; Regenerative Medicine","2025-11-17",{"date":92,"type":93},"2025-11-21","ACTUAL",{"date":95,"type":93},"2025-02-01",{"date":97,"type":81},"2028-02-01",{"name":5,"class":6},1]