Brain Network fMRI Analysis in Proprioceptive Training for Chronic Low Back Pain

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorThe Fourth Affiliated Hospital of Zhejiang University School of Medicine

About this trial

Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically reveals the central neural remodeling patterns in CNLBP and establishes an objective efficacy evaluation system based on multimodal imaging.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age between 18 and 60 years old;

Current or past low back pain lasting more than three months; ③ No abnormal sensation or reflex abnormalities in the lower limbs; ④ Able to commit to participating in training three times per week for three months.

Disqualifiers

Fractures, dislocations, structural abnormalities, prior surgery, metal implants, or lumbar disc herniation;

Comorbidities such as severe cardiovascular diseases, neurological disorders, osteoporosis, or metabolic diseases; ③ Low back pain caused by visceral diseases;

VAS score (range 1-10) exceeding 8 points;

Pregnant or lactating women; ⑥ Symptoms of nerve root irritation; ⑦ Recent participation in core stability training.

Trial population

All patients were assigned numbers from 1 to 40. Starting at any row and column in a random number table, 40 random numbers were sequentially recorded in correspondence with the patient numbers. The random numbers were then ranked in ascending order, with ranks 1-20 assigned to the experimental group and ranks 21-40 to the control group. All patients continued to receive conventional treatment and comprehensive rehabilitation therapy.

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

  • Multimodal Imaging Evaluation

    Other intervention

    Functional connectivity analysis of brain networks based on functional magnetic resonance imaging (fMRI) technology

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

VAS

The Visual Analogue Scale (VAS) was used to assess the severity of low back pain, with 0 indicating no pain and 10 indicating unbearable severe pain.

Time frame
After 4 weeks of treatment
2

JOA

The Japanese Orthopaedic Association (JOA) efficacy assessment criteria for low back disorders were applied to evaluate lumbar function.

Time frame
After 4 weeks of treatment

Secondary outcomes

1

MRI

Magnetic resonance imaging was used to assess the effects of treatment on brain networks.

Time frame
After 4 weeks of treatment

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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