BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age16+
SponsorUniversity of Chicago
About this trial
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago). Biospecimens will undergo biomarker analysis - biomarker data specific to PBI is extremely limited, and could provide critical insight to outcome identification and clinical decision making.
This data will be used to build the first comprehensive PBI Data Commons, biorepository, and imaging repository which will create the infrastructure necessary to close critical knowledge gaps, advance biomarker discovery specific to PBI, and provide the foundation for future research aimed at improving prognostication and treatment for patients with this devastating injury.
Eligibility criteria
Qualifiers
Age: Subjects aged 16 years and older
Injury Type/Evidence: Patients with a confirmed PBI as demonstrated by head imaging or physical exam (evidence of dural penetration by a projectile)
Timeframe: Patients must be enrolled within 8 hours of injury
Disqualifiers
Dead on Arrival (DOA): Patients who receive CPR with no return of pulse
Non-penetrating injury: Patients with head injuries that do not include dural penetration
Polytrauma: Patients with penetrating or blunt injuries to other parts of the body
Known or suspected pregnancy
Trial design
Treatments tested in this trial
- Blood Sample Collection
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov