[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610804":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":10,"locations":19,"responsibleParty":40,"collaborators":10,"id":44,"slug":10,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":10,"eligibilityCriteria":48,"healthyVolunteers":45,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":22,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"Benha University","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"adult patients admitted to the ICU with post-operative secondary peritonitis requiring an ICU stay o",null,[12],"Diagnostic Test: Capillary Leak Index Versus",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Capillary Leak Index Versus","Blood samples will be collected at three time points: within 1-2 hours of ICU admission (Day 0), Day 1, Day 2 and Day 7, to monitor trends in CLI and conventional biomarkers during the ICU stay. • CR",[9],[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Benha University Hospital","RECRUITING","Banhā","Qalyubia Governorate","13511","Egypt","EG",{"type":29,"coordinates":30},"Point",[31,32],31.1842,30.45977,{"lat":32,"lon":31},[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Samar assistant professor, MD","CONTACT","+201287793991","samar.rafik@gmail.com",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Samar Rafik Mohamed Amin","Dr","100610804",false,"NCT07232342","Capillary Leak Index Versus Conventional Biomarkers in Predicting Sepsis-Related Outcomes","Inclusion Criteria:\n\nAge ≥ 18 years.\n\nPostoperative secondary peritonitis requiring ICU admission, with clinical evidence of:\n\nDiffuse or localized abdominal pain\u002Ftenderness. Peritoneal signs (e.g., guarding, rigidity, rebound tenderness). Imaging or intraoperative confirmation of purulent\u002Fexudative intra-abdominal fluid.\n\nSystemic inflammation (e.g., fever, leukocytosis, or vasopressor requirement). Sepsis diagnosis per Sepsis-3 criteria: Suspected\u002Fconfirmed infection with acute increase in SOFA score ≥2 points (6).\n\nAnticipated ICU stay ≥48 hours postoperatively.\n\nExclusion Criteria:\n\n* Pregnancy\n\n  * Advanced liver disease (Child-Pugh class B or C) that might independently affect albumin levels\n  * Advanced kidney disease (CKD stage 4 or 5) or patients on chronic dialysis\n  * Expected mortality within 48 hours of ICU admission\n  * Patients with primary peritonitis or tertiary peritonitis\n  * Immunocompromised patients (e.g., on chronic immunosuppressive therapy, solid organ transplant recipients, patients with HIV and CD4 count \\\u003C200\u002Fmm³)\n  * Patients with pre-existing systemic inflammatory diseases that might affect baseline CRP levels\n  * Patients participating in interventional trials that might affect outcomes","ALL","18 Years",{"count":52,"type":53},100,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the prognostic significance of CLI in predicting 28-day mortality and other outcomes in critically ill patients who develop post-operative abdominal sepsis.",[57],"Peritonitis Infectious",[59,60,61,62],"Peritonitis","Capillary Leak Index","Conventional Biomarkers","Critically Ill Patients","2025-11-17",{"date":65,"type":66},"2025-11-18","ACTUAL",{"date":68,"type":53},"2025-12-10",{"date":70,"type":53},"2026-10-30",{"name":5,"class":6},1]