[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558752":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":29,"centralContacts":34,"locations":42,"responsibleParty":60,"collaborators":24,"id":63,"slug":24,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":24,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":24,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Bispebjerg Hospital","OTHER",[8,14],{"label":9,"type":6,"description":10,"interventionNames":11},"Group randomized to begin with MRI","Group is randomized to begin with MRI and have PET\u002FCT performed later on the same day",[12,13],"Procedure: MRI","Procedure: PET\u002FCT",{"label":15,"type":6,"description":16,"interventionNames":17},"Group randomized to begin with PET\u002FCT","Group is randomized to begin with PET\u002FCT and have MRI performed later on the same day",[12,13],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","MRI","MRI will be performed",[9,15],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"PET\u002FCT","PET\u002FCT will be performed",[9,15],[30],{"name":31,"affiliation":32,"role":33},"Ali Asmar, MD, PhD","Bispebjerg Hospital, Department of Clinical Physiology and Nuclear Medicine","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Peter Sørensen, MD","CONTACT","+4530516279","peter.soerensen@regionh.dk",{"name":31,"role":37,"phone":24,"phoneExt":24,"email":41},"ali.asmar@regionh.dk",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Bispebjerg Hospital, Department of Clinical Physiology & Nuclear Medicine","RECRUITING","Copenhagen","Capital Region","2400","Denmark","DK",{"type":52,"coordinates":53},"Point",[54,55],12.56553,55.67594,{"lat":55,"lon":54},[58,59],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},{"name":31,"role":37,"phone":24,"phoneExt":24,"email":41},{"type":33,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Ali Asmar","Chief Physician, Associate Professor","100558752",false,"NCT06555211","Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET\u002FCT and MRI","Cardio and Renovascular Effects of Static Muscle Work in the Healthy Human - Measured With Finapres® and Positron Emission Tomography (PET) Using 15-oxygen Labeled Water as Tracer Compared to Magnetic Resonance (MR)","Inclusion Criteria:\n\n* Normal health stated through medical questionnaire, examination and blood samples.\n\nExclusion Criteria:\n\n* Immunosuppressive treatment\n* Alcohol abuse\n* Treatment with glucocorticoids, Glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase 4 (DPP-4)-inhibitors\n* Medical treatment affecting insulin secretion or cardiovascular endpoints\n* Liver disease\n* Decreased kidney function\n* Severe claustrophobia\n* Elements incompatible with MR.",true,"MALE","18 Years","60 Years",{"count":74,"type":75},10,"ESTIMATED","INTERVENTIONAL",[78],"NA","This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET\u002FCT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI technique.\n\nThe study will determine:\n\n* Total renal blood flow and regional renal perfusion at baseline (rest) and during isometric muscle exercise of the upper arm, using PET\u002FCT (with 15-oxygen labeled water as a tracer) and MRI.\n* The coefficient of variation of renal blood flow and regional renal perfusion measurements at baseline and during isometric muscle exercise of the upper arm, using PET\u002FCT (with 15-oxygen labeled water as a tracer) and MRI.\n* Regional renal oxygenation and oxygen extraction at baseline and during isometric muscle exercise of the upper arm using MRI.\n* The coefficient of variation on regional renal oxygenation and oxygen extraction measurements at baseline and during isometric muscle exercise of the upper arm using MRI.",[81],"Kidneys",[83,84,85,86],"Total renal blood flow","Regional renal perfusion","Regional renal oxygenation","Renal oxygen extraction","2024-08-12",{"date":89,"type":90},"2024-08-15","ACTUAL",{"date":92,"type":90},"2024-05-07",{"date":94,"type":75},"2024-12",{"name":5,"class":6},1]