The aim of the study is to investigate the effect of coenzyme Q10 supplementation (150 mg/b.i.d, 300 mg/d, 12 weeks) on coenzyme Q10, glucose parameters, BDNF, myokines, and cognitive function in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients who combined with hyperglycemia but without sarcopenia, or with hyperglycemia and pre-sarcopenia.
Clinical diagnosis of mild cognitive impairment (MCI).
Clinical diagnosis of Alzheimer's Disease.
MCI and AD patients with hyperglycemia ( Fasting glucose >=100 mg/dL).
MCI and AD patients with pre-sarcopenia (low calf circumference, low hand grip, or low muscle endurance).
Cancer patients.
Severe heart, lung, liver, and kidney diseases.
Severe disability or aphasia.
Malnutrition (body weight changes > 5% within one month).
Crossover
Coenzyme Q10
Dietary supplement300 mg/day (150mg/b.i.d)
Placebo
Other interventionStarch, dextrin
Fasting glucose
Fasting glucose will measured by an automated chemistry analyzer.
HbA1C
HbA1C will measured by an automated glycated hemoglobin analyzer.
Insulin
Insulin will measured by chemiluminescence assay.
C-peptide
C-peptide will measured by chemiluminescence assay.
Malondialdehyde (MDA) level
MDA will measured by thiobarbituric acid reacting substance.
Advanced Glycation End Products (AGEs) level
AGE level will measured by competitive enzyme-linked immunosorbent assay.
Total antioxidant capacity
Total antioxidant capacity will measured by a Trolox equivalent antioxidant capacity assay.
Mini-Mental State Examination (MMSE) score
The maximum score for the MMSE is 30. A score of 25 or higher is classed as normal. If the score is below 24, the result is usually considered to be abnormal, indicating possible cognitive impairment.
ATP level
ATP level will measured by ATP determination kit.
Citrate synthase level
Citrate synthase level will measured by Citrate Synthase Assay Kit.
Quality of Life in Alzheimer's Disease Measure (QOL-AD)
The QOL-AD score is the sum of all 13 items. Higher scores mean participants are more satisfied with their quality of life.
Geriatric Depression Scale (GDS)
The GDS score is the sum of all 15 items. Higher scores indicate a tendency for participants to feel depressed.
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Chung Shan Medical University
Lead sponsor
National Science and Technology Council
Collaborator
