[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100511369":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":49,"collaborators":52,"id":55,"slug":20,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":20,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":20,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":20,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Active cerebellum rTMS","EXPERIMENTAL","Cerebellar targeted iTBS, once daily, one week",[13],"Device: Repetitive Transcranial Magnetic Stimulation (rTMS)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Repetitive Transcranial Magnetic Stimulation (rTMS)","rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces an electrical current in neurons and allows for modulation of neural circuitry.\n\nOther Name: iTBS",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Laura Holsen, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","617-525-8772","lholsen@bwh.harvard.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"McLean Hospital","RECRUITING","Belmont","Massachusetts","02478","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-71.17867,42.39593,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":20,"phoneExt":20,"email":48},"Mark Halko, PhD","mhalko@mclean.harvard.edu",{"type":24,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Laura M Holsen","Associate Professor of Psychiatry",[53],{"name":54,"class":6},"Foundation for Prader-Willi Research","100511369",false,"NCT05938543","Cerebellar TMS and Satiety in Prader-Willi Syndrome","Noninvasive Neuromodulation of a Novel Cerebellar Satiety Circuit in Prader-Willi Syndrome","Inclusion Criteria:\n\n* Diagnosis of Prader-Willi syndrome\n\nExclusion Criteria:\n\n* contraindications for TMS or MRI including :\n* history of neurological disorder\n* history of head trauma resulting in loss of consciousness\n* history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy\n* metal in brain or skull\n* implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI","ALL","18 Years","64 Years",{"count":65,"type":66},20,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome.\n\nTMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.",[72],"Prader-Willi Syndrome","2025-12-01",{"date":75,"type":76},"2025-12-05","ACTUAL",{"date":78,"type":76},"2023-09-01",{"date":80,"type":66},"2026-10",{"name":5,"class":6},1]