Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFirst Affiliated Hospital of Wannan Medical College

About this trial

Patients with end-stage renal disease (ESRD) often require arteriovenous grafts (AVG) for hemodialysis. AVG thrombosis is a common complication, usually managed by percutaneous transluminal angioplasty (PTA) to restore blood flow. PTA achieves patency by balloon-mediated compression and fragmentation of thrombus. Small thrombus fragments may enter the venous circulation and cause transient pulmonary microembolism, leading to ventilation-perfusion (V/Q) mismatch. This study uses electrical impedance tomography (EIT) to noninvasively monitor short-term changes in regional ventilation and perfusion during and after PTA, exploring the immediate pulmonary physiological consequences of thrombus fragmentation and revascularization in dialysis patients.

Eligibility criteria

Qualifiers

Age ≥ 18 years.

Diagnosis of end-stage renal disease receiving maintenance hemodialysis.

Documented AVG thrombosis requiring PTA.

Able to cooperate and tolerate EIT monitoring.

Disqualifiers

Severe respiratory failure incompatible with supine position.

Thoracic skin condition or deformity preventing EIT electrode placement.

Acute pulmonary embolism or acute pulmonary edema before procedure.

NYHA Class IV heart failure or hemodynamic instability.

Trial design

Treatments tested in this trial

  • Electrical Impedance Tomography (EIT) Monitoring

Treatment groups

20 Participants
are divided into 1 treatment group