[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589552":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":26,"centralContacts":30,"locations":40,"responsibleParty":61,"collaborators":64,"id":68,"slug":10,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":10,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":10,"enrollmentInfo":76,"targetDuration":10,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Columbia University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Walkers",null,"Participants with SMA who are able to walk without assistance.",[13],"Other: Observational",{"label":15,"type":10,"description":16,"interventionNames":17},"Sitters","Participants with SMA who are unable to walk without assistance, but are able to sit independently.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Non-sitters","Participants with SMA who are unable to sit without assistance.",[13],[23],{"type":6,"name":24,"description":24,"armGroupLabels":25,"otherNames":10},"Observational",[19,15,9],[27],{"name":28,"affiliation":5,"role":29},"Jacqueline Montes, Pt, EdD","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Rafael Rodriguez-Torres, DPT","CONTACT","3472877093","rsr2157@cumc.columbia.edu",{"name":37,"role":33,"phone":38,"phoneExt":10,"email":39},"Cara Kanner, DPT","516-581-8150","chy2112@cumc.columbia.edu",[41],{"facility":42,"status":43,"city":44,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Columbia University Irving Medical Center","RECRUITING","New York","10032","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-74.00597,40.71427,{"lat":52,"lon":51},[55,59],{"name":56,"role":33,"phone":57,"phoneExt":10,"email":58},"Jacqueline Montes, PT EdD","2123058916","jm598@cumc.columbia.edu",{"name":32,"role":33,"phone":60,"phoneExt":10,"email":35},"347-287-7093",{"type":29,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jacqueline Montes","Professor of Rehabilitation and Regenerative Medicine",[65],{"name":66,"class":67},"Biogen","INDUSTRY","100589552",false,"NCT06955897","Characterizing Perceived Physical Fatigability in Nusinersen-treated SMA","Characterizing Perceived Physical Fatigability in Nusinersen-treated Adolescents and Adults: The SMA EFFORT","Inclusion Criteria:\n\n1. All types of 5qSMA (homozygous deletion or point mutation of the SMN1 gene and any number of SMN2 copies)\n2. Receiving a stable dosing regimen of 12 or 28 mg nusinersen for at least 6 months\n\nExclusion Criteria:\n\n1. An injury or surgery within the previous 3 months that would impact their ability to perform in-clinic function and\u002For fatigability assessments\n2. Enrolled in an ongoing clinical trial, or extension study, expanded access program, or long-term registry of an investigational or recently approved medication\n3. Receiving adjuvant and\u002For dual therapy (e.g., muscle-targeted, NMJ, or symptomatic treatments)","ALL","12 Years",{"count":77,"type":78},45,"ESTIMATED","OBSERVATIONAL","The purpose of this project is to investigate the utility of the SMA EFFORT, an SMA-specific patient-reported outcome measure, to assess perceived physical fatigability that is anchored to intensity and duration of activities. We aim to characterize perceived physical fatigability (PPF) in a diverse cohort of people with SMA (pwSMA) and evaluate the change of PPF before and after nusinersen dosing.",[82],"Spinal Muscular Atrophy",[84,85,86,87,88,89,90],"spinal muscular atrophy","neuromuscular disease","nusinersen","fatigability","exercise","SMA","fatigue","2026-05-12",{"date":93,"type":94},"2026-05-14","ACTUAL",{"date":96,"type":94},"2025-04-24",{"date":98,"type":78},"2027-02-26",{"name":5,"class":6},1]