[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644160":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":10,"responsibleParty":29,"collaborators":10,"id":31,"slug":10,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":36,"eligibilityCriteria":37,"healthyVolunteers":38,"sex":39,"minAge":40,"maxAge":10,"enrollmentInfo":41,"targetDuration":44,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":50,"overallStatus":54,"whyStopped":10,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":10},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intracerebral Hemorrhage Group",null,"Adults with intracerebral hemorrhage confirmed by head CT or MRI, admitted within 24 hours after symptom onset, and prospectively enrolled after informed consent. Peripheral venous blood samples (4-5 mL) will be collected, and clinical and imaging data will also be obtained.",[13],"Other: Blood Sample Collection",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Control Group","Age-eligible healthy controls recruited prospectively from the hospital health examination center after informed consent. One peripheral venous blood sample (4-5 mL) will be collected, together with basic demographic and health-related information.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Blood Sample Collection","Peripheral venous blood sample collection for biomarker measurement only; no investigational treatment is administered.",[15,9],[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Guohua Wang, MD, PhD","CONTACT","+86 13581749398","wangguohua@xwhosp.org",{"type":30,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100644160",false,"NCT07665255","CIRP and Cathepsin B in Neuroinflammation After Intracerebral Hemorrhage","A Prospective Observational Case-Control Study of Peripheral Blood CIRP, Cathepsin B, and Related Inflammatory Biomarkers in Patients With Intracerebral Hemorrhage","CIRP-ICH","Inclusion Criteria:\n\nIntracerebral hemorrhage group:\n\nAge 18 years or older Diagnosis of intracerebral hemorrhage confirmed by head CT or MRI Supratentorial hemorrhage No surgical treatment Hematoma volume less than 30 mL Admission within 24 hours after symptom onset The participant or the legally authorized representative\u002Fnext of kin is able to provide written informed consent\n\nHealthy control group:\n\nAge 18 years or older Recruited from the hospital health examination center No history of stroke, intracerebral hemorrhage, cerebral infarction, or other major neurological diseases No severe active infection, severe immune disease, hematologic disease, or end-stage severe heart, liver, or renal failure No acute infection, trauma, or other obvious stress state within the previous 2 weeks Able to provide written informed consent\n\nExclusion Criteria:\n\nIntracerebral hemorrhage group:\n\nTraumatic intracerebral hemorrhage Secondary intracerebral hemorrhage caused by brain tumor, cerebrovascular malformation, aneurysm, or hemorrhagic transformation of infarction Severe active infection, severe immune disease, or hematologic disease End-stage severe heart, liver, or renal failure Pregnant or lactating women Any other condition judged unsuitable by the investigator\n\nHealthy control group:\n\nHistory of stroke, intracranial hemorrhage, brain tumor, or other major neurological diseases Severe active infection, severe immune disease, or hematologic disease End-stage severe heart, liver, or renal failure Pregnant or lactating women Any other condition judged unsuitable by the investigator",true,"ALL","18 Years",{"count":42,"type":43},60,"ESTIMATED","1 Day","OBSERVATIONAL","This is a single-center, investigator-initiated, prospective observational case-control study. Patients with intracerebral hemorrhage and healthy controls will be enrolled at Xuanwu Hospital, Capital Medical University. Peripheral venous blood samples will be collected for measurement of CIRP, Cathepsin B, and related inflammatory biomarkers. Clinical and imaging data will also be collected in the intracerebral hemorrhage group. The study aims to compare biomarker levels between patients with intracerebral hemorrhage and healthy controls and to explore the potential role of these biomarkers in neuroinflammation after intracerebral hemorrhage. No investigational treatment will be administered.",[48,49],"Intracerebral Hemorrhage","Nontraumatic Intracerebral Hemorrhage",[51,52,53],"Neuroinflammation","cirp","Cathepsin B","NOT_YET_RECRUITING","2026-06-22",{"date":57,"type":58},"2026-06-24","ACTUAL",{"date":60,"type":43},"2026-07-01",{"date":62,"type":43},"2028-12-31",{"name":5,"class":6}]