Cognition and Ultrasound
ConditionHealthy Participants
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Minnesota
About this trial
Our primary goal is to investigate the role of Low-Intensity Focused Ultrasound (LIFU) neuromodulation on deep brain targets, and its potential to improve cognition
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18 years of age or older
Speak English (as assessed by their ability to read/answer survey questions)
May be required to score in the appropriate range on self-report measures
Disqualifiers
They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults.
They take any psychoactive medication.
They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder.
Are pregnant, or may have reason to believe that they are pregnant.
Trial design
Design model
Single group
Treatments tested in this trial
Low-Intensity Focused Ultrasound (FUS or LIFU)
DeviceWe will use an established, currently-marketed device to deliver LIFU neuromodulation.
Treatment groups
100 Participants
are divided into 1 treatment groupGroup A: Low-Intensity Focused UltrasoundExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Deep Brain Targets Reached
MRI-based readouts testing whether LIFU neuromodulation can successfully engage targets in deep brain
Time frame
Hour 12
Multi-Source Interference Test (MSIT) Performance
Behavioral readouts of successful LIFU neuromodulation of our target regions
Time frame
Hour 13
28/Posit Science Performance
Behavioral readouts of successful LIFU neuromodulation of our target regions
Time frame
Hour 1Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov