[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100502448":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":52,"collaborators":10,"id":54,"slug":10,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Parkinson's Disease undergoing DBS",null,"This study will recruit 55 patients with Parkinson's disease (PD) participants who will undergo DBS surgery and and are scheduled for a pre-DBS neuropsychological evaluation at MUSC.",[13],"Procedure: Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care",{"label":15,"type":10,"description":16,"interventionNames":10},"Healthy Control participants without Parkinson's Disease","This study will recruit 25 healthy controls (age-matched) to serve as a comparison of baseline cognitive and neuroimaging measures.",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care","Participants in this study will already be undergoing a DBS intervention, however, this is part of their standard clinical care. Pre-surgical DBS candidates that enroll in this study will consent to participate in 1) pre-operative neuroimaging including a high-resolution MRI scan, 2) collection of pre-operative neurocognitive data via chart review and 3) a 1-year postoperative neurocognitive assessment.",[9],[24],{"name":25,"affiliation":5,"role":26},"Daniel H Lench, PhD","PRINCIPAL_INVESTIGATOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","843-792-9115","lenchd@musc.edu",{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},"Gonzalo J Revuelta, DO","843-792-7262","revuelta@musc.edu",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-79.93275,32.77632,{"lat":48,"lon":47},[51],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100502448",false,"NCT05822388","Cognitive Decline Following Deep Brain Stimulation","A Neural Basis for Cognitive Decline Following Deep Brain Stimulation","PD Participants\n\nInclusion Criteria:\n\n* Subjects above 18 years of age\n* Subjects who will undergo DBS surgery as part of their clinical care for PD\n\nExclusion Criteria:\n\n* Uncorrected visual or hearing impairments, as indicated by self-report\n* Individuals who are pregnant or expect to become pregnant during the course of the study\n* Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner\n* COPD with oxygen dependence\n* Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)\n\nNon-PD Control Participants\n\nInclusion Criteria:\n\n* Subjects above 18 years of age\n* Age matched to participants in PD group\n\nExclusion Criteria:\n\n* Diagnosis of Parkinsons Disease or other movement disorder\n* Untreated neuropsychiatric disorders\n* Uncorrected visual or hearing impairments, as indicated by self-report\n* Individuals who are pregnant or expect to become pregnant during the course of the study\n* Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner\n* COPD with oxygen dependence\n* Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)",true,"ALL","18 Years",{"count":64,"type":65},80,"ESTIMATED","OBSERVATIONAL","This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.",[69,70],"Parkinson Disease","Movement Disorders","2026-05-27",{"date":73,"type":74},"2026-05-29","ACTUAL",{"date":76,"type":74},"2023-04-01",{"date":78,"type":65},"2027-03-31",{"name":5,"class":6},1]