Collagen Cross-linking in Keratoconus
ConditionKeratoconus
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorOregon Health and Science University
About this trial
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.
Eligibility criteria
Qualifiers
Diagnosis of keratoconus
Minimum corneal thickness of 410 microns
Disqualifiers
Inability to maintain fixation for OCT imaging
Inability to commit to required study visits
Inability to give informed consent
Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery
Trial design
Treatments tested in this trial
- Laser Custom Corneal Collagen Cross-Linking
Treatment groups
100 Participants
are divided into 1 treatment groupSponsors and collaborators
Oregon Health and Science University
Lead sponsor
National Eye Institute (NEI)
Collaborator
Source ClinicalTrials.gov