[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100301727":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":60,"collaborators":62,"id":66,"slug":10,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":10,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":10,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Southern California","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Ancillary-correlative (biospecimen collection)",null,"Patients and healthy normal volunteers undergo collection of peripheral blood samples for analysis via flow cytometry, RNASeq, immunohistochemistry, CyTOF experiments, cell cultures, and functional studies of immune cell subsets obtained by FACS. Patients also undergo collection of bone marrow and leukopheresis\u002Fleukoreduction specimens, and single cell suspensions and bulk excised tumor biopsies are obtained from routine testing for analysis via immunohistochemistry or CyTOF.",[13,14,15],"Procedure: Biospecimen Collection","Other: Laboratory Biomarker Analysis","Other: Questionnaire Administration",[17,22,26],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"PROCEDURE","Biospecimen Collection","Undergo collection of peripheral blood, bone marrow, and tissue",[9],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Laboratory Biomarker Analysis","Correlative studies",[9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Questionnaire Administration","Ancillary studies",[9],[31],{"name":32,"affiliation":5,"role":33},"Casey O'Connell, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Arta Zenunovic","CONTACT","323-442 7828","Arta.zenunovic@med.usc.edu",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"USC \u002F Norris Comprehensive Cancer Center","RECRUITING","Los Angeles","California","90033","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-118.24368,34.05223,{"lat":53,"lon":52},[56,58],{"name":36,"role":37,"phone":57,"phoneExt":10,"email":39},"323-442-5771",{"name":59,"role":33,"phone":10,"phoneExt":10,"email":10},"Casey O'Connell, MS",{"type":61,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[63],{"name":64,"class":65},"National Cancer Institute (NCI)","NIH","100301727",false,"NCT03207854","Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers","Protocol for Immunology Specimen Collection From Cancer Patients, Patients With Hematologic Diagnoses, and Healthy Normal Controls","Inclusion Criteria:\n\n* All patients known to have cancer, an immune-mediated hematologic diagnosis, or a healthy normal volunteer\n* Definition of immune-mediated hematologic diagnosis: diagnoses for which immune dysfunction and\u002For immune system directed therapy (eg. aplastic anemia, autoimmune hemolytic anemia, immune thrombocytopenic purpura \\[ITP\\], etc.) are involved\n* Definition of healthy normal volunteer: persons lacking diagnoses of any type of cancer, diabetes, cardiovascular diseases, non-hematologic autoimmune disease (eg. systemic lupus erythematosus \\[SLE\\], rheumatoid arthritis \\[RA\\], Crohn's disease) and not taking any immunosuppressive medications\n* Patients must have been seen in the Norris Hospital and outpatient clinics, or the Los Angeles County (LAC)-University of Southern California (USC) Medical Center or outpatient clinics; healthy volunteers can be recruited without any physician visit appointments since their labs are strictly for clinical research and not for personal health issues unrelated to the project\n\nExclusion Criteria:\n\n* Unable to give informed consent to specimen collection\n* Known human immunodeficiency virus (HIV) positive status\n* Persons taking any type of immunosuppressive medication are excluded from participating as healthy normal volunteers\n* Any patient for whom specimen collection is judged to be unsafe (for example, for patients unable to establish venous access)",true,"ALL","19 Years",{"count":76,"type":77},625,"ESTIMATED","OBSERVATIONAL","This research trial collects and stores blood, tissue, and bone marrow specimens from patients with cancer or blood disorders, and healthy volunteers to study the immune system in a variety of different types of experiments, as well as associated clinical data as appropriate, focused on understanding mechanisms of immunotherapy.",[81,82,83,84,85],"Healthy Subject","Hematologic and Lymphocytic Disorder","Hematopoietic and Lymphoid Cell Neoplasm","Immune System Disorder","Malignant Neoplasm","2026-03-27",{"date":88,"type":89},"2026-04-02","ACTUAL",{"date":91,"type":89},"2017-04-12",{"date":93,"type":77},"2027-12-31",{"name":5,"class":6},1]