[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580480":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":59,"collaborators":30,"id":63,"slug":30,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":30,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":30,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":30,"overallStatus":45,"whyStopped":30,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Kafrelsheikh University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Group ITD","EXPERIMENTAL","Patients will receive 15mg in 3ml hyperbaric bupivacaine intrathecally with 5 μg in 0.5ml dexmedetomidine + adductor canal block using 20 ml saline 0.9% at the end of surgery",[13],"Drug: Intrathecal Dexmedetomidine",{"label":15,"type":16,"description":17,"interventionNames":18},"Group ACB","ACTIVE_COMPARATOR","Patients will receive 15mg in 3ml hyperbaric bupivacaine intrathecally with 0.5ml saline 0.9% + adductor canal block using 20 ml bupivacaine 0.25% at the end of surgery.",[19],"Drug: Adductor Canal Block",{"label":21,"type":10,"description":22,"interventionNames":23},"Group ITD+ACB","Patients will receive 15mg in 3ml hyperbaric bupivacaine intrathecally with 5 μg in 0.5ml dexmedetomidine + adductor canal block using 20 ml bupivacaine 0.25% at the end of surgery.",[24],"Drug: Intrathecal Dexmedetomidine + Adductor Canal Block",[26,31,34],{"type":27,"name":28,"description":11,"armGroupLabels":29,"otherNames":30},"DRUG","Intrathecal Dexmedetomidine",[9],null,{"type":27,"name":32,"description":17,"armGroupLabels":33,"otherNames":30},"Adductor Canal Block",[15],{"type":27,"name":35,"description":22,"armGroupLabels":36,"otherNames":30},"Intrathecal Dexmedetomidine + Adductor Canal Block",[21],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Sherif K Arafa, MD","CONTACT","00201005714014","Sherifhafez1980@gmail.com",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Kafr ash Shaykh","Kafrelsheikh","33516","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],30.93991,31.11174,{"lat":55,"lon":54},[58],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Sherif Kamal Arafa","Assistant Professor of Anesthesiology, Surgical Intensive Care and Pain Management Department, Faculty of Medicine, KafrElsheikh University, KafrElsheikh, Egypt.","100580480",false,"NCT06837844","Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty","Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 75 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Scheduled for total knee arthroplasty under spinal anesthesia.\n\nExclusion Criteria:\n\n* Patients with neurological or intellectual disability.\n* History of allergy to local anesthetics or dexmedetomidine .\n* Infection at the injection site.\n* Prolonged use of analgesic or sedative medications.\n* Coagulation abnormalities.\n* Pregnancy.\n* Obesity \\[body mass index (BMI) \\> 30 kg\u002Fm2\\].","ALL","18 Years","75 Years",{"count":73,"type":74},75,"ESTIMATED","INTERVENTIONAL",[77],"NA","The aim of this work is to evaluate the effect of combined intrathecal dexmedetomidine and adductor canal block for analgesia after total knee arthroplasty (TKA).",[28,32,80,81],"Analgesia","Total Knee Arthroplasty","2025-02-20",{"date":84,"type":85},"2025-02-21","ACTUAL",{"date":82,"type":85},{"date":88,"type":74},"2025-08-01",{"name":5,"class":6},1]