[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641181":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":24,"locations":29,"responsibleParty":49,"collaborators":24,"id":52,"slug":24,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":24,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":24,"enrollmentInfo":60,"targetDuration":24,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":75,"overallStatus":87,"whyStopped":24,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pressure Controlled Ventilation","ACTIVE_COMPARATOR","During invasive mechanical ventilation in the cardiac ICU, pressure-controlled ventilation will be used as the mode for continuous mandatory ventilation.",[13],"Other: Pressure Controlled Mode",{"label":15,"type":10,"description":16,"interventionNames":17},"Volume-Controlled Ventilation","During invasive mechanical ventilation in the cardiac ICU, volume-controlled ventilation will be used as the mode for continuous mandatory ventilation.",[18],"Other: Volume Controlled Mode",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Volume Controlled Mode","Volume-controlled mode for continuous mandatory ventilation with preset inspiratory flow and tidal volume.",[15],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Pressure Controlled Mode","Pressure-controlled mode for continuous mandatory ventilation with preset inspiratory pressure above positive end-expiratory pressure.",[9],[30],{"facility":31,"status":24,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Mayo Clinic, 1216 Second Street SW","Rochester","Minnesota","55905","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-92.4699,44.02163,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":24,"email":48},"Garima Dahiya","CONTACT","507-255-1051","dahiya.garima@mayo.edu",{"type":50,"investigatorFullName":45,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Assistant Professor of Medicine","100641181",false,"NCT07656259","COMPARE-VENT Feasibility Pilot Study","COMPARE-VENT Feasibility Pilot Study: A Pragmatic Cluster Randomized Crossover Trial for Ventilation Strategies and Hemodynamic Impact in Critically Ill Patients With Cardiovascular Disease","Inclusion Criteria:\n\nEligible adults ≥ 18 years of age admitted to the cardiac ICU with need for invasive mechanical ventilation of expected duration \\>12 hours.\n\nPre-Specified Subgroups for exploratory outcomes:\n\n1. SCAI Stages C-E Cardiogenic Shock\n2. Mechanical circulatory support use, including intra-aortic balloon pumps and microaxial flow pumps, including Impella CP, RP Impella Flex, and Impella 5.5 devices\n3. Heart failure with reduced ejection fraction: LVEF \\\u003C40% or;\n4. Moderate to severe RV systolic dysfunction or;\n5. Moderate to severe Pulmonary hypertension, as defined by ACC\u002FAHA\u002FESC guidelines\n\nExclusion Criteria:\n\n1. Expected duration of intubation \\\u003C12 hours.\n2. Severe COPD, bronchopleural fistulas, or severe ARDS (Berlin criteria P\u002FF \\\u003C100, in the absence of pulmonary edema)\n3. Home ventilator or chronic tracheostomy.\n4. Pregnant, incarcerated, patients or those receiving extracorporeal membrane oxygenation","ALL","18 Years",{"count":61,"type":62},75,"ESTIMATED","INTERVENTIONAL",[65],"NA","Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among patients with impaired cardiovascular reserve is further compounded by the adverse impact of positive pressure ventilation (PPV) and systemic sedation on intracardiac hemodynamics, pulmonary vascular mechanics and consequently end-organ perfusion. Despite widespread use, evidence guiding optimal ventilatory practices and mode selection in cardiovascular intensive care unit patients remains limited. Pressure-controlled and volume-controlled ventilation may differ in their effects on patient-ventilator synchrony, sedation requirements, and hemodynamic impact, but comparative data among patients with critical cardiac disease remains inconclusive. This pilot study will evaluate the feasibility of implementing a pragmatic cluster-randomized crossover trial comparing ventilatory modes in a contemporary cardiovascular intensive care unit.",[68,69,70,71,72,73,74],"Respiration Failure","Cardio Vascular Disease","Cardiogenic Pulmonary Oedema","Critical Illness","Mechanical Ventilation","Cardiogenic Shock","Cardiopulmonary",[76,77,78,79,80,81,82,83,84,85,86],"Cardiovascular disease","Cardiac arrest","Cardiogenic shock","Respiratory failure","Cardiopulmonary interactions","Critical illness","Intensive care unit","Critical care therapies","Outcomes","Mechanical ventilation","Positive pressure ventilation","NOT_YET_RECRUITING","2026-06-14",{"date":90,"type":91},"2026-06-18","ACTUAL",{"date":93,"type":62},"2026-07-01",{"date":95,"type":62},"2027-06-30",{"name":5,"class":6},1]