[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500545":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":24,"responsibleParty":42,"collaborators":46,"id":50,"slug":10,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":73,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Heart Failure-Associated Pleural Effusion",null,"Patients with pleural effusion with an underlying aetiology of heart failure",{"label":13,"type":10,"description":14,"interventionNames":10},"Control group","Patients with pleural effusion due to exudative, or non-fluid overload causes",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Christopher Chan, MBChB","CONTACT","35053396","christopherchan@cuhk.edu.hk",{"name":22,"role":18,"phone":19,"phoneExt":10,"email":23},"Ken KP Chan, MBChB","chankapang@cuhk.edu.hk",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":28,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Prince of Wales Hospital","RECRUITING","Hong Kong","New Territories","0000","HK",{"type":33,"coordinates":34},"Point",[35,36],114.17469,22.27832,{"lat":36,"lon":35},[39],{"name":17,"role":18,"phone":40,"phoneExt":41,"email":20},"85235052211","7607",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Christopher Chan","Honorary Clinical Tutor",[47],{"name":48,"class":49},"Roche Diagnostics GmbH","INDUSTRY","100500545",false,"NCT05797649","Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)","Comparing N-terminal-proB-type Natriuretic Peptide with Other Diagnostic Criteria in Discriminating Heart Failure-associated from Non-heart Failure-associated Pleural Effusions","Inclusion Criteria:\n\n* Patients hospitalized for heart failure and pleural effusion\n* Pleural tapping indicated for pleural fluid analysis.\n* Aged 18 years old or above\n\nExclusion Criteria:\n\n* History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.\n* History of surgical decortication or pleurodesis in the ipsilateral pleural space.\n* Ipsilateral thoracic or cardiac surgery in the past 3 months.\n* Failure to obtain informed consent due to the patient's refusal or cognitive impairment.","ALL","18 Years",{"count":59,"type":60},120,"ESTIMATED","24 Months","OBSERVATIONAL","To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).",[65,66,67,68,69,70,71,72],"Pleural Effusion","Heart Failure","Malignant Neoplasm","Fluid Overload","Hypoalbuminemia","Renal Failure","Cirrhosis","Infections",[74,75,76,77,78,79,80,81],"pleural fluid","heart failure","malignancy","cancer","echocardiography","infection","tuberculosis","respiratory medicine","2024-11-11",{"date":84,"type":85},"2024-11-13","ACTUAL",{"date":87,"type":85},"2023-07-01",{"date":89,"type":60},"2025-11-30",{"name":5,"class":6},1]