This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies. The study evaluates the effectiveness and safety of continuous ablative radiofrequency, which uses heat energy to disrupt pain signals, and chemical denervation with absolute alcohol, which involves an injection to reduce pain transmission. Participants will be randomly assigned to one of the treatments, and their pain levels, mobility, and quality of life will be monitored over time to determine which method provides better pain relief.
Adults aged ≥ 18 years.
Knee pain for more than 3 months.
Clinical and imaging-confirmed diagnosis of knee osteoarthritis, based on X-ray, ultrasound, or magnetic resonance imaging (MRI).
History of major joint interventions, such as previous knee surgery or arthroplasty.
Severe joint effusion.
Coagulation disorders or other clinical contraindications for the procedure.
Uncontrolled comorbidities that increase procedural risk.