[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643654":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":44,"locations":53,"responsibleParty":73,"collaborators":30,"id":76,"slug":30,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":30,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":30,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":98,"overallStatus":56,"whyStopped":30,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Ankara Etlik City Hospital","OTHER_GOV",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Group F (Fentanyl Group)","EXPERIMENTAL","Patients in this group are assigned to receive intravenous (IV) Patient-Controlled Analgesia (PCA) using a fentanyl solution. The treatment is initiated either at the 6th postoperative hour or upon the first request for analgesia (VAS \\>4). This arm is the potent opioid-based treatment group.",[13],"Drug: Fentanyl IV PCA",{"label":15,"type":10,"description":16,"interventionNames":17},"Group T (Tramadol Group)","Patients in this group are assigned to receive IV PCA using a tramadol solution. Similar to Group F, the protocol is initiated at the 6th postoperative hour or at the first analgesic demand. This arm represents the weak opioid-based approach.",[18],"Drug: Tramadol IV PCA",{"label":20,"type":10,"description":21,"interventionNames":22},"Group I (Ibuprofen Group)","Patients in this group are assigned to receive IV PCA using an ibuprofen solution. Similar to Group F and T, the protocol is initiated at the 6th postoperative hour or at the first analgesic demand. This arm is the non-opioid, NSAID-based treatment group.",[23],"Drug: Ibuprofen IV PCA",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Fentanyl IV PCA","Patients receive intravenous Patient-Controlled Analgesia (PCA) using a fentanyl solution (4 mcg\u002Fml), initiated at the 6th postoperative hour (or earlier if VAS \\>4) and continued for 72 hours.\n\nBasal infusion rate: 0.2 μg\u002Fkg\u002Fh Demand bolus dose: 20 μg Lockout interval: 20 minutes",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Tramadol IV PCA","Patients receive intravenous PCA using a tramadol solution (2 mg\u002Fml), initiated at the 6th postoperative hour (or earlier if VAS \\>4) and continued for 72 hours.\n\nBasal infusion rate: 10 mg\u002Fh Demand bolus dose: 10 mg Lockout interval: 20 minutes",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Ibuprofen IV PCA","Patients receive intravenous PCA using an ibuprofen solution (2 mg\u002Fml), initiated at the 6th postoperative hour (or earlier if VAS \\>4) and continued for 72 hours.\n\nBasal infusion rate: 20 mg\u002Fh Demand bolus dose: 10 mg Lockout interval: 20 minutes",[20],[40],{"name":41,"affiliation":42,"role":43},"Dilek Unal, MD, Prof.","University of Health Sciences, Ankara Etlik City Hospital","PRINCIPAL_INVESTIGATOR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":30,"email":49},"Baris Turunc, MD","CONTACT","+90 5300202777","baris.turunc94@gmail.com",{"name":41,"role":47,"phone":51,"phoneExt":30,"email":52},"+90 5336957855","dilekunalmd@gmail.com",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":30,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Ankara Etlik City Hospital, Department of Anesthesiology and Reanimation","RECRUITING","Ankara","Keçiören","06010","Turkey (Türkiye)",{"type":62,"coordinates":63},"Point",[64,65],32.85427,39.91987,{"lat":65,"lon":64},[68,69,70,71],{"name":46,"role":47,"phone":48,"phoneExt":30,"email":49},{"name":41,"role":47,"phone":51,"phoneExt":30,"email":52},{"name":41,"role":43,"phone":30,"phoneExt":30,"email":30},{"name":46,"role":72,"phone":30,"phoneExt":30,"email":30},"SUB_INVESTIGATOR",{"type":43,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Barış Turunç","MD","100643654",false,"NCT07610408","Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery","Comparison of the Effectiveness of Intravenous Analgesia Protocols Used After the Duration of Block Action for Postoperative Pain Control in Thoracic Surgery","Inclusion Criteria:\n\n1. \\- Patients aged 18 to 80 years.\n2. \\- ASA (American Society of Anesthesiologists) Physical Status Score of I-III.\n3. \\- Body Mass Index (BMI) between 18 and 35 kg\u002Fm².\n4. \\- Undergoing elective thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS).\n5. \\- Voluntary participation confirmed by signing the written Informed Consent Form.\n\nExclusion Criteria:\n\n1. \\- Age below 18 or above 80 years.\n2. \\- Advanced organ failure (e.g., severe hepatic or renal impairment).\n3. \\- ASA physical status \\> III.\n4. \\- History of chronic pain treatment or long-term opioid use.\n5. \\- BMI \\\u003C 18 kg\u002Fm² or \\> 35 kg\u002Fm².\n6. \\- Pregnancy or breastfeeding.\n7. \\- Limited cooperation due to dementia or uncontrolled psychiatric disorders.\n8. \\- Communication barriers (inability to communicate in the native language).\n9. \\- History of substance or drug abuse.\n10. \\- Known allergy or contraindication to the study drugs (Fentanyl, Tramadol, or Ibuprofen).\n11. \\- Contraindication to regional block placement (e.g., infection at the injection site).","ALL","18 Years","80 Years",{"count":86,"type":87},135,"ESTIMATED","INTERVENTIONAL",[90],"NA","The purpose of this study is to compare the effectiveness of three different intravenous (IV) patient-controlled analgesia (PCA) regimens-Fentanyl, Tramadol, and Ibuprofen-in managing postoperative pain and respiratory performance in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS). While regional blocks like Erector Spinae Plane (ESP) block provide effective early analgesia, their effect typically diminishes after 8-12 hours, leading to potential 'rebound pain.' This study specifically investigates the period following the duration of the regional block's action. The primary goal is to evaluate which IV PCA protocol better controls pain (Visual Analog Scale scores) and supports better respiratory performance (measured by incentive spirometry) during the first 72 hours post-surgery",[93,94,95,96,97],"Postoperative Pain After Thoracic Surgery","Postoperative Pain","Thoracic Surgery, Video Assisted","Patient Controlled Analgesia","Acute Pain",[99,100,101,102,103,104,105,106,107,108,109],"Video-Assisted Thoracoscopic Surgery","VATS","Erector Spinae Plane Block","ESP","Patient-Controlled Analgesia","PCA","IV analgesia","Incentive spirometry","Opioid-sparing","Postoperative pain after thoracic surgery","Rebound Pain","2026-06-06",{"date":112,"type":113},"2026-06-09","ACTUAL",{"date":115,"type":113},"2026-06-02",{"date":117,"type":87},"2026-10-15",{"name":5,"class":6},1]