[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608202":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":14,"collaborators":7,"id":17,"slug":7,"hasResults":18,"nctId":19,"briefTitle":20,"officialTitle":21,"acronym":22,"eligibilityCriteria":23,"healthyVolunteers":18,"sex":24,"minAge":25,"maxAge":7,"enrollmentInfo":26,"targetDuration":29,"studyType":30,"phases":7,"briefSummary":31,"conditions":32,"keywords":34,"overallStatus":36,"whyStopped":7,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":7},{"fullName":5,"class":6},"First People's Hospital of Chenzhou","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Xingui Dai","CONTACT","18175708210","20685562@qq.com",{"type":15,"investigatorFullName":10,"investigatorTitle":16,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","The department of Critical Care Medicine","100608202",false,"NCT07198490","Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring","Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring: A Prospective Observational Study","CPM-Brain","Inclusion Criteria:\n\n* Diagnosis of severe TBI, large-volume stroke, or HIE\n* Expected ICU stay \\>72 hours\n* Informed consent from legal surrogate\n\nExclusion Criteria:\n\n* Terminal organ failure\n* Pre-existing severe neurological disease\n* Skull defect preventing monitoring\n* Pregnancy or lactation","ALL","18 Years",{"count":27,"type":28},50,"ESTIMATED","8 Months","OBSERVATIONAL","This is a prospective, observational cohort study aimed at constructing a machine learning-based prognostic model for severe brain-injured patients. The study will synchronously collect continuous glucose monitoring (CGM), electroencephalography (EEG), near-infrared spectroscopy (fNIRS), transcranial Doppler (TCD), and serum neuronal injury biomarkers (NSE, S100β) within 72 hours post-injury. The goal is to investigate the correlation between glycemic variability (GV) and neurological function and to develop an integrated model for early prediction of 3-6 month neurological outcomes (GOSE score).",[33],"Brain Injuries",[35],"continuous glucose monitoring,Neurological Multimodal Monitoring,Brain Injury,Intensive Care Unit","NOT_YET_RECRUITING","2025-09-29",{"date":39,"type":40},"2025-09-30","ACTUAL",{"date":42,"type":28},"2025-10-01",{"date":44,"type":28},"2026-12-31",{"name":10,"class":6}]