INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.
Age ≥65 years
ASA physical status III or IV
Chronic arterial hypertension
Diabetes mellitus requiring medication
Pregnancy
Cardiac arrhythmia
History of intracranial hemorrhage or intracranial aneurysm
Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)