[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100528802":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":63,"collaborators":65,"id":69,"slug":25,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":91,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Barts & The London NHS Trust","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Convergent AF Ablation with Left Atrial Appendage Exclusion","EXPERIMENTAL","Two Staged Convergent AF Ablation Procedure\n\nStage 1 - Minimally Invasive Surgical Epicardial Ablation Procedure with concomitant LAA exclusion (LARIAT procedure)\n\nStage 2 - Percutaneous Endocardial Catheter Ablation",[13,14],"Device: Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device.","Procedure: Standard Endocardial Catheter Ablation",{"label":16,"type":17,"description":16,"interventionNames":18},"Standard Endocardial Catheter Ablation","ACTIVE_COMPARATOR",[14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device.","2 stage procedure - minimally-invasive epicardial ablation with left atrial appendage exclusion using LARIAT procedure via a subxiphoid incision. This is then combined with endocardial radiofrequency catheter ablation in a separate staged procedure.",[9],null,{"type":27,"name":16,"description":28,"armGroupLabels":29,"otherNames":25},"PROCEDURE","Standard percutaneous endocardial catheter ablation of atrial fibrillation",[9,16],[31],{"name":32,"affiliation":33,"role":34},"Syed Ahsan","Consultant Cardiologist and Electrophysiologist, Barts Health NHS Trust","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","020 7377 7000","syedahsan@nhs.net",{"name":41,"role":37,"phone":38,"phoneExt":25,"email":42},"Shahana Hussain","shahana.hussain2@nhs.net",[44],{"facility":45,"status":46,"city":47,"state":25,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"St Bartholomew's Hospital","RECRUITING","London","EC1A 4AS","United Kingdom","UK",{"type":52,"coordinates":53},"Point",[54,55],-0.12574,51.50853,{"lat":55,"lon":54},[58,59,60],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":34,"phone":25,"phoneExt":25,"email":25},{"name":61,"role":62,"phone":25,"phoneExt":25,"email":25},"Nikolaos Papageorgiou","SUB_INVESTIGATOR",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[66],{"name":67,"class":68},"AtriCure, Inc.","INDUSTRY","100528802",false,"NCT06165510","Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation","CLIP-AF","Inclusion Criteria:\n\n* Age \\> 18 years; \\\u003C 80 years\n* Persistent AF \\> 1-year duration\n* Left atrium size \\\u003C 6cm\n* Pts should be able to provide written informed consent.\n\nExclusion Criteria:\n\n* Subjects currently enrolled in another investigational study except in case of observational registry with no associated treatments.\n* Subject has a reversible cause of AF or transient AF\n* Subject is absent of LAA or if the LAA is previously surgically ligated\n* Subject has had previous cardiac surgery or abdominal surgery.\n* Subject has contraindication to anticoagulation.\n* Patients with hypertrophic cardiomyopathy.\n* Patients with significant valve disease.\n* Subject has had previous catheter or surgical ablation",true,"ALL","18 Years","80 Years",{"count":80,"type":81},48,"ESTIMATED","INTERVENTIONAL",[84],"NA","A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).",[87,88,89,90],"Persistent Atrial Fibrillation","Atrial Fibrillation, Persistent","Atrium; Fibrillation","Atrial Arrhythmia",[92,93,94,95,96],"Catheter ablation","Convergent procedure","Left atrial appendage","Hybrid ablation","Cardiac arrhythmias","2026-06-24",{"date":99,"type":100},"2026-06-25","ACTUAL",{"date":102,"type":100},"2024-08-02",{"date":104,"type":81},"2026-11",{"name":5,"class":6},1]