[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636759":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":64,"collaborators":26,"id":66,"slug":26,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":26,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mannitol Infusion","EXPERIMENTAL","Diagnostic evaluation of polyuria polydipsia syndrome through copeptin measurement after mannitol infusion.",[13],"Diagnostic Test: Mannitol",{"label":15,"type":16,"description":17,"interventionNames":18},"Hypertonic Saline Infusion (HIS)","ACTIVE_COMPARATOR","Diagnostic evaluation of polyuria polydipsia syndrome through copeptin measurement after HIS",[19],"Diagnostic Test: Hypertonic Saline",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIAGNOSTIC_TEST","Mannitol","Intravenous infusion of 1.5g\u002Fkg body weight (max. 120g) mannitol is given over 30 minutes (≙ 7.5ml\u002Fkg body weight).",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Hypertonic Saline","Intravenous infusion of NaCl 3% is given first as a bolus of 250ml over 15 minutes, then with an infusion rate of 0.15ml\u002Fkg body weight \u002F minute (≙ 9ml\u002Fkg body weight\u002Fhour).",[15],[32],{"name":33,"affiliation":34,"role":35},"Mirjam Christ-Crain, Prof. Dr.","University Hospital of Basel","STUDY_CHAIR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Talitha Hildebrandt","CONTACT","+41 61 55 65075","talithanatalja.hildebrandt@usb.ch",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Cemile Bathelt","+41 61 55 65407","cemile.bathelt@usb.ch",[47],{"facility":48,"status":49,"city":50,"state":26,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University Hospital Basel","RECRUITING","Basel","4031","Switzerland","CH",{"type":55,"coordinates":56},"Point",[57,58],7.57327,47.55839,{"lat":58,"lon":57},[61,62],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},{"name":33,"role":63,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100636759",false,"NCT07569861","Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome","COMPASS","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Hypotonic polyuria\u002Fpolydipsia syndrome defined as polyuria \\>40ml\u002Fkg body weight\u002F24h and polydipsia \\>3l\u002F24h; and urine osmolality \\\u003C800mOsm\u002FL or known AVP-D based on accepted criteria\n\nExclusion Criteria:\n\n1. Polyuria\u002Fpolydipsia secondary to diabetes mellitus, hypercalcemia, or hypokalemia\n2. Diagnosis of AVP-R (Copeptin \\> 21.4 pmol\u002FL)\n3. Evidence of acute illness\n4. Epilepsy requiring treatment\n5. Uncontrolled arterial hypertension (blood pressure \\>160\u002F100mmHg at baseline\n6. eGFR \\\u003C 60 ml\u002Fmin\u002F1,73 m2\n7. Cardiac failure (NYHA III-IV)\n8. Diagnosis of liver cirrhosis, Child-Pugh Class C\n9. Uncorrected adrenal or thyroidal deficiency\n10. Pregnancy or breastfeeding\n11. Current or unresolved urinary obstruction\n12. Enrollment in a clinical trial within the last 30 days\n13. Patients refusing or unable to give written informed consent\n14. Inability to follow study procedures","ALL","18 Years",{"count":75,"type":76},144,"ESTIMATED","INTERVENTIONAL",[79],"NA","The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which test patients prefer. The goal is to identify a simpler and more patient-friendly diagnostic approach.",[82,83],"Arginine Vasopressin Deficiency","Primary Polydipsia",[85,86,23,87],"Copeptin Measurement","Diagnosis of Polyuria-polydipsia syndrome","Hypertonic Saline Infusion","2026-06-17",{"date":90,"type":91},"2026-06-18","ACTUAL",{"date":93,"type":91},"2026-06-16",{"date":95,"type":76},"2030-06",{"name":5,"class":6},1]