The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston keratoprosthesis (KPro) type I against corneal melting (keratolysis or sterile necrosis).
Candidate for KPro type I
Capacity to give written consent
Ability to be followed for the duration of the study
Participation in another interventional study
Failure to wear a therapeutic contact lens due to abnormalities of the eyelids.
Inability to give written consent
Severe dryness with keratinization of the ocular surface
Parallel
Crosslinking with riboflavin of the corneal graft-support
Procedure/SurgeryCorneal graft support for the KPro will be crosslinked and used with the standard surgical technique
De-epithelisation of the corneal graft support with instillation of riboflavin
Procedure/SurgeryCorneal graft-support will be de-epithelialized and soaked with riboflavin and then used with the standard surgical technique
Examine whether the use of crosslinked cornea decreases the rate of corneal melting post-Kpro when compared to using a standard corneal button
This visit will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
Examine whether the use of crosslinked cornea decreases the rate of corneal melting post-Kpro when compared to using a standard corneal button
This visit will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
Examine whether the use of crosslinked cornea decreases the rate of corneal melting post-Kpro when compared to using a standard corneal button
This visit will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
Examine whether the use of crosslinked cornea decreases the rate of corneal melting post-Kpro when compared to using a standard corneal button
This visits will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
Comparison of the rates of infectious keratitis between the groups
This visit will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
Comparison of the rates of infectious keratitis between the groups
This visit will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
Comparison of the rates of infectious keratitis between the groups
This visit will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
Comparison of the rates of infectious keratitis between the groups
This visit will include measurement of visual acuity and intraocular pressure and a full slit-lamp examination.
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Centre hospitalier de l'Université de Montréal (CHUM)
Lead sponsor
Maisonneuve-Rosemont Hospital
Collaborator
