Countermeasures to Circadian Misalignment
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorColorado State University
About this trial
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.
Eligibility criteria
Qualifiers
18-35 old; men and women; equal numbers of women and men will be included.
Body Mass Index (BMI) between 20.0 and 24.9 ("normal" weight).
Physical activity history: inactive to habitual moderate physical activity level
Sleep/wake history: habitual sleep duration between 7-9.25 hours.
Disqualifiers
Any clinically significant medical, psychiatric, or sleep disorder
Use of prescribed medications/supplements/illicit drugs within one month prior to study
History of shift work in year prior to study, or travel more than one time zone in three weeks prior to study. [NOTE: Subjects can be studied at a later date.]
Women with history of prior gynecological pathology, <1 year post-partum, breast-feeding and/or pregnant.
Trial design
Treatments tested in this trial
- Time-restricted feeding
- Circadian Misalignment
Treatment groups
32 Participants
are divided into 2 treatment groupsSponsors and collaborators
Colorado State University
Lead sponsor
University of Colorado, Denver
Collaborator
Salk Institute for Biological Studies
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov